Sebasti an SLODKI, Joanna BOGUCKA

Bir Köpekte Kalın Bağırsak Nöroendokrin Tümörü

Bu makale, karaciğer yetmezliği ve kronik kanlı ishal nedeniyle kliniğe kabul edilen 5 yaşındaki bir Standart Schnauzer köpeğindenöroendokrin tümör teşhisini açıklamaktadır. İlk muayeneye bağlı tanı konulamadığı için köpeğin gastrointestinal sistemininendoskopik muayenesi yapıldı. Endoskopik muayenede ostium ileocaecolicum içerisinde bir tümöre rastlandı. Ne yazık ki, bu işlemdenkısa bir süre sonra, hayvanın ölümüne yol açan büyük bir kanama meydana geldi. Otopside tümörün varlığı doğrulandı. Alınanörneklerin histopatolojik ve immünohistokimyasal analizi sonucu, kalın bağırsakta bir nöroendokrin tümör (NET G1) belirlendi. Sonuçolarak, köpeklerde gastrointestinal karsinoidler nispeten nadirdir ve karmaşık veya spesifik olmayan semptomatolojisi nedeniylesıklıkla yanlış teşhis edilirler.

Neuroendocrine Tumor of the Large Intestine in a Dog

This paper describes the diagnosis and treatment of a 5-year-old Standard Schnauzer dog admitted to the clinic due to a liver failure and chronic bloody diarrhea. Based on the initial examination, no diagnosis could be made, therefore an endoscopic examination of the gastrointestinal tract was performed. The endoscopy revealed a tumor within the ostium ileocaecocolicum. Unfortunately, shortly after this procedure, a massive hemorrhage occurred, which led to the animal’s death. The necropsy confirmed the presence of the tumor. The histopathological and immunohistochemical results of the collected specimens showed a neuroendocrine tumor (NET G1) of the large intestine. In conclusion, gastrointestinal carcinoids in dogs are relatively rare and often misdiagnosed due to complex or non-specific symptomatology.

PDF

___

1. Modlin IM, Oberg K, Chung DC, Jensen RT, de Herder WW, Thakker RV, Caplin M, Delle Fave G, Kaltsas GA, Krenning EP, Moss SF, Nilsson O, Rindi G, Salazar R, Ruszniewski P, Sundin A: Gastroenteropancreatic neuroendocrine tumors. Lancet Oncol, 9, 61-72, 2008. DOI: 10.1016/ S1470-2045(07)70410-2
2. Kuwata K, Shibutani M, Kemmochi Y, Taniai E, Morita R, Ogawa B, Mitsumori K: A neuroendocrine carcinoma of undetermined origin in a dog. J Toxicol Pathol, 23 (3): 151-155, 2010. DOI: 10.1293/tox.23.151
3. Dasari A, Shen C, Halperin D, Zhao B, Zhou S, Xu Y, Shih T, Yao JC: Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States. JAMA Oncol, 3 (10): 1335-1342,2017. DOI: 10.1001/jamaoncol.2017.0589
4. Head KW, Else RW, Dubielzig RR: Tumors of the alimentary tract. In, Meuten DJ (Ed): Tumors in Domestic Animals. 4th ed., 401-481, Iowa State Press, Ames, IA, 2002.
5. Schott M, Klöppel G, Raffel A, Saleh A, Knoefel WT, Scherbaum WA: Neuroendocrine neoplasms of the gastrointestinal tract. Dtsch Arztebl Int, 108 (18): 305-312, 2011. DOI: 10.3238/arztebl.2011.0305
6. Plöckinger U, Rindi G, Arnold R, Eriksson B, Krenning EP, de Herder WW, Goede A, Caplin M, Oberg K, Reubi JC, Nilsson O, Delle Fave G, Ruszniewski P, Ahlman H, Wiedenmann B: Guidelines for the diagnosis and treatment of neuroendocrine gastrointestinal tumours.Neuroendocrinology, 80, 394-424, 2004. DOI: 10.1159/000085237
7. Leoncini E, Carioli G, La Vecchia C, Boccia S, Rindi G: Risk factors for neuroendocrine neoplasms: A systematic review and meta-analysis. Ann Oncol, 27, 68-81, 2016. DOI: 10.1093/annonc/mdv505
8. Garcia-Carbonero R, Capdevila J, Crespo-Herrero G, Díaz-Pérez JA, Martínez Del Prado MP, Alonso Orduña V, Sevilla-García I, VillabonaArtero C, Beguiristain-Gómez A, Llanos-Muñoz M, Marazuela M, Alvarez-Escola C, Castellano D, Vilar E, Jiménez-Fonseca P, Teulé A, Sastre-Valera J, Benavent-Viñuelas M, Monleon A, Salazar R: Incidence, patterns of care and prognostic factors for outcome of gastroenteropancreatic neuroendocrine tumours (GEP-NETs): Results from the National Cancer Registry of Spain (RGETNE). Ann Oncol, 21 (9): 1794-1803, 2010. DOI: 10.1093/annonc/mdq022
9. Nagtegaal ID, Odze RD, Klimstra D, Paradis V, Rugge M, Schirmacher P, Washington KM, Carneiro F, Cree IA: The 2019 WHO classification of tumours of the digestive system. Histopathology, 76 (2): 182-188, 2020. DOI: 10.1111/his.13975