Bu çalışmada bazı yerel anestezik (lidokain, bupivakain, prilokain) ilaçların ratlarda mesane üzerine in vitro etkileri araştırıldı. Denemeler izole organ banyosu ortamında gerçekleştirildi. Lidokain, bupivakain ve prilokain'in 6 farklı dozu denendi. Lidokainin 2. dozu (0.6 $\mu$g/ml) hariç diğer bütün dozları (1. doz: 0.2 $\mu$g/ml. 3. doz: 2 $\mu$g/ml. 4. doz: 6 $\mu$g/ml. -5. doz: 20 $\mu$g/ml, 6. doz: 60 $\mu$g/ml) mesane kaslarında gevşemeye neden oldu. Lidokainin 3. dozunun (p

In this study, in vitro effects of liclocaine, bupivacaine and prilocaine on the urinary bladder muscle in rats were examined. The experiments were performed in isoloated organ-bath. Six different doses were tried for each local anesthetic. All doses of lidocaine (1. doz: 0.2 ug/ml. 3. doz: 2 $\mu$g/ml. 4. doz: 6 $\mu$g/ml, 5. doz: 20 $\mu$g/ml, 6. doz 60 $\mu$g/ml) except 2nd dose (0.6 $\mu$g/ml) caused relaxation on bladder muscles. The relaxation effects of the third (p<0.05), 4th and 6th (p<0.01) doses of the lidocaine were significant. It was observed that first (0.25 $\mu$g/ml), 5th (15 $\mu$g/ml) 6th (30 $\mu$g/ml) doses of bupivacaine showed relaxation, whereas 2nd (0.5 $\mu$g/ml), 3rd (1.5 $\mu$g/ml) and 4th (5 $\mu$g/ml) doses of this drug caused contractions on urinary bladder muscles. While first (0.5 $\mu$g/ml), 5th (30 $\mu$g/ml) and 6th (60 $\mu$g/ml) doses of prilocaine showed relaxation, 2rd (1 $\mu$g/ml) and 3rd (3 $\mu$g/ml) doses caused contractions. The 4th closes of this drug showed no sings of either relaxation or contraction. Only 6th doses of the prilocaine showed statistically significant relaxation (p<0.01).