İNSANDAKİ KRONİK İNORGANİK ARSENİK İNTOKSİKASYONUNUN BAZI BİYOKİMYASAL VE FİZYOLOJİK PARAMETRELERE ETKİLERİNİN ARAŞTIRILMASI

Bu çalışmada uzun süre yüksek oranda arsenikli içme suyu ile inorganik arseniğe maruz kalan kişilerde bazı biyokimyasal parametre ve kan basınç değerlerinde meydana gelen değişimlerin araştırılması amaçlandı. Çalışmada kronik arseniğe maruz kalan kişiler ve kontrol grubu olmak üzere iki grup oluşturularak değerler gruplar arası kıyaslandı. Çalışmaya katılan kişilerden venöz kan alınarak, serumlarında kan glukozu, trigliserit ve total kolesterol seviyeleri belirlendi. Ayrıca bu kişilerin tansiyonu ölçülerek diastolik ve sistolik kan basınç değerleri tespit edildi. Kronik arseniğe maruz kalanlarda kontrol grubuna göre kan glukozu, trigliserit ve total kolesterol seviyeleri ile kan basınç değerlerinin yüksek olduğu tespit edildi. Kronik olarak arseniğe maruz kalan kişiler ile kontrol grubu değerleri ortalamaları sırasıyla kan glukoz düzeyleri 139,90 ± 36,22 mg/dl vs 96,86 ± 21,90 mg/dl, trigliserit düzeyleri 189,28 ± 43,76 mg/dl vs 131,33 ± 35,14 mg/dl, total kolestrol düzeyleri 156,34 ± 29,61 mg/dl vs 118,53 ± 46,15 mg/dl, diastolik kan basıncı 81,92 ± 10,59 mm Hg vs 71,50 ± 7,27 mm Hg, sistolik kan basıncı 138,46 ± 21,59 mm Hg vs 114,50 ± 13,07 mm Hg olarak tespit edildi. Yapılan istatistiksel analiz sonucunda değerlerin anlamlı (p<0,001) olduğu tespit edildi. Sonuç olarak uzun süre içme suyundaki yüksek orandaki inorganik arseniğin insanlarda biyokimyasal parametreleri olumsuz yönde etkilediği ve arseniğin oluşturduğu oksidatif strese bağlı olarak bu kişilerde farklı hastalıkların oluşma riskini arttırabileceğini söyleyebiliriz.

Anahtar Kelimeler:

Arsenik, İntoksikasyon, Biyokimyasal parametreler, Kan basıncı

RESEARCH FOR THE EFFECTS OF CRONIC INORGANIC ARSENIC INTOXICATION ON CERTAIN BIOCHEMICAL AND PHYSIOLOGICAL PARAMETERS

In this study, it was aimed to research the changes in some biochemical parameters and blood pressure values of those exposed to inorganic arsenic by drinking water involving high level of arsenic for a long time. Forming two groups- the control group and the one composed of those exposed to chronic arsenic, the values were compared between the groups. By taking venous blood samples from the subjects, blood glucose, triglyceride and total cholesterol levels were determined in their serums. Also, by taking their blood pressure, their diastolic and systolic blood pressure values were determined. It was found that those exposed to chronic arsenic had higher blood glucose, triglyceride, total cholesterol levels and blood pressure values than the control group. The mean values of those exposed to chronic arsenic and the control group were as follows respectively: blood glucose levels 139.90 ± 36.22 mg/dl vs 96.86 ± 21.90 mg/dl, triglyceride levels 189.28 ± 43.76 mg/dl vs 131.33 ± 35.14 mg/dl, total cholesterol levels 156.34 ± 29,61 mg/dl vs 118.53 ± 46.15 mg/dl, diastolic blood pressure 81.92 ± 10.59 mm Hg vs 71.50 ± 7.27 mm Hg, and systolic blood pressure 138.46 ± 21.59 mm Hg vs 114.50 ± 13.07 mm Hg. As a result of statistical analysis, the values were determined to be significant (p<0.001). Consequently, it can be said that a long term exposure to high amount of inorganic arsenic in drinking water have adverse effects on the biochemical parameters in humans and that the risk of different ailments in these subjects may increase depending on the oxidative stress caused by arsenic.

Keywords:

Arsenic, Intoxication, Biochemical parameters, Blood pressure,

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