Vanilloid Reseptör 1 (VR1) (Capsaicin Reseptörü)

Vanilloid Reseptör-1, capsaicin ve capsaicine benzer etki oluşturabilen, ısı ve asit ile aktive olan bir iyon kanal reseptörüdür. Vanilloidlerin bağlandığı reseptörlere vanilloid reseptör denir. Vanilloidler ekzojen ve endojen olarak ikiye ayrılır. TRPV1 (Transient receptor potential vanilloid receptor-1) ilk olarak dorsal root, trigeminal ve nodos gangliyonlarda eksprese edilmiş, seçici olmayan iyon kanal proteinidir. Capsaicin’in spesifik olarak bağlandığı reseptöre capsaicin reseptörü ya da vanilloid reseptör 1 (TRPV1 ya da VR1) adı verilmiştir. VR1, 426 aminoasit içeren ve ~ 95 kDa ağırlığında bir proteindir. VR1, 430C’nin üzerindeki sıcaklıkta ve düşük pH’da (pH≤5) oluşan membran depolarizasyonu ve iyon kanallarının açılması sonucu capsaicin tarafından aktive edilir. VR1 ilk olarak santral sinir sistemindeki nöyronlarda ortaya konulmuştur. Ancak son zamanlarda yapılan çalışmalar VR1’in mast hücreleri, derideki keratinositler ve idrar kesesi epitel hücreleri gibi nöyron içermeyen çeşitli hücrelerde de bulunduğunu göstermiştir

Anahtar Kelimeler:

capsaicin, vanilloid reseptör, Capsaicin Reseptörü

Vanilloid Receptor

Vanilloid receptor-1 is a heat-and acid-activated ion channel receptor, which creates capsaicin and can create an effect like-capsaicin. Connected to vanilloid receptors are called vanilloid receptor. The vanilloids are divided to exogenous and endogenous. TRPV1 (transient receptor potential vanilloid receptor-1) is a nonselective ion channel protein that has firstly been expressed on dorsal root, trigeminal and nodos ganglia. The receptor which is connected specifically by capsaicin is called Capsaicin receptor or vanilloid receptor. VR1 is a ~ 95 kDa protein which includes 426 aminoacide. As a result of over 430C and low pH (pH≤5) ,VR1 is activated by capsaicin. Because at that time membrane is depolarized and ion channels are opened. VR1 was first shown in the neurons of the central nervous system. However, recent studies show that VR1 is expressed in non neuronal various cells; mast cells, keratinocytes in the skin and epithelial cells in the bladder .

Keywords:

Capsaicin, vanilloid, receptor,

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