Maja MITRAŠINOVIĆ BRULIĆ, Anida KULOVAC, Damir SULJEVIĆ

Chronic effects of tramadol hydrochloride/paracetamol oral administration on haematological parameters and glucose level in Wistar rats

Tramadol hydrochloride/paracetamol is an opioid that is composed of two different analgesics, tramadol(opioid, 37.5 mg) and paracetamol (non opioid, 325 mg). The study presents first data of tramadolhydrochloride/paracetamol effects on haematological parameters and glucose levels in Wistar rats. Oral administrationad libitum of tramadol hydrochloride/paracetamol was administered during a twenty days period. This researchincludes two groups of animals. Group I include animals that were administered tramadol hydrochloride/paracetamoldaily at dosage of 1.12 g/300 ml and group II that were administered daily at dosage of 1.68 g/300 ml of water. Weanalayzed 14 haematological parameters and glucose concentration. Significant changes were established for allanalyzed parameters. Significantly low numbers of erythrocytes, leukocytes and lymphocytes were observed. Tramadolhydrochloride/paracetamol has an extremely negative effect on haematological parameters in Wistar rats, particularilyon the blood coagulation due to the thrombocitopenia, anaemia and weakened immunity. If properly administered,tramadol hydrochloride/paracetamol can be an effective analgesic but at high dosage and over a prolonged period itmay cause adverse effects in Wistar rats.

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