Burç Çağrı POYRAZ, Armağan ÖZDEMİR, Alaattin DURAN, Cana POYRAZ AKSOY, Deniz Uluhan YILDIRIM

Impairment of Executive Functions and Memory in Unaffected Siblings of Patients with Bipolar Disorder

Amaç: İki uçlu bozukluk hastalarında nörobilişsel bozukluklar muhtemel bir endofenotip adayı olarak görülmekteve bu konuda araştırmalar gitgide artmaktadır. İki uçlubozukluk hastalarının yakınlarında belirlenen yürüytücüişlevler ve hafızada bozuklukları bu göstergelerin genetikçalışmalarda kullanılabilecek muhtemel endofenotiplerolabileceğini düşündürtmektedir. Bu çalışmada iki uçlubozukluk tip 1 tanısı konulmuş hastaların sağlıklı olankardeşlerine uygulanan nöropsikolojik değerlendirmelersağlıklı kişilerden oluşan kontrol grubuyla karşılaştırılmıştır.Yöntem: İki uçlu bozukluk tip 1 tanısı konulmuş 35 hastanın sağlıklı olan kardeşi ve 35 kişiden oluşan sağlıklıkontrol grubuna sözel akıcılık, dikkat, yürütücü işlevler vehafıza işlevlerine yönelik testler uygulanmıştır. Uygulanantestler arasında Rey İşitsel Sözel Öğrenme Testi, WechslerBellek Ölçekleri görsel bellek uzamı alt testi, Stroop Testi,İz sürme testi A ve B formları, Wechsler Zeka Ölçekleri SayıDizileri alt testleri, kategorik akıcılık testi (Isaac SET Test)ve saat çizme testi yer almaktadır.Bulgular: İki uçlu bozukluğu olan hastaların sağlıklı kardeşleri, kontrol grubuna göre Rey İşitsel Sözel Öğrenme Testi,Wechsler Bellek Ölçekleri görsel bellek uzamı hatırlamaalt testinde, Stroop Testi, İz sürme testi A ve B formları,Wechsler Zeka Ölçekleri Sayı Dizileri düz sayı menzilitestinde daha düşük bir başarı sergiledi. Basamaklı lojistikregresyon analizinde TMT-B testindeki başarı tek başınahastaların kardeşlerini sağlıklı kişilerden güçlü bir orandaayırabiliyordu.Sonuç: İki uçlu bozukluk hastalarının kardeşlerinde İzsürme testi-B ile ölçülen set değiştirme becerisinde önemlibir bozulma bulduk. Çalışma bulgularımıza göre set değiştirme/bilişsel esneklik iki uçlu bozuklukta bilişsel işlevlerarasından bir endofenotip adayı olabilir.

İki uçlu bozukluk hastalarının hasta olma- yan kardeşlerinde yürütücü işlev ve hafıza bozuklukları

Objective: Neurocognitive impairments in bipolar patientsas a possible endophenotype is a growing field of research.Impairments in executive functions and memory havebeen reported in relatives of patients with bipolar disorder,suggesting that they could be potential endophenotypesfor genetic studies. In this study, neuropsychologicalperformance in unaffected siblings of patients diagnosedas bipolar I disorder is compared to that of matchedhealthy controls.Method: We evaluated 35 unaffected siblings of probandswith bipolar I disorder and 35 healthy controls usingtests of verbal fluency, attention, executive functionsand memory. Rey Auditory Verbal Learning Test (RAVLT),Wechsler Memory Scale-Revised (WMS-R) visual memorytest, Stroop Colour-Word Interference test (SCWIT), TrailMaking Test-A and B, Wechsler Adult Intelligence Scale- Revised Digit Span test, categoric verbal fluency test (IsaacSET Test) , and clock drawing tests were performed.Results: Unaffected siblings of patients with bipolardisorder performed poorly on the RAVLT, SCWIT, forwardDigit Span Test, TMT-A and B, visual recall test. Usingstepwise logictic regression TMT-B alone could highlydifferentiate siblings from controls.Conclusion: We found significant impairment of setshifting task measured with TMT-B in siblings of patientswith BD. Our study suggests that set shifting/cognitiveflexibility could be a potential cognitive endophenotypefor bipolar disorder.

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