Hatice Türk DAĞI, Mehmet DAĞLI, Ayşe Rüveyda UĞUR, İnci TUNCER

Miyelodisplastik sendromlu bir hastada Campylobacter fetus subsp. fetus'e bağlı bir bakteriyemi: Olgu sunumu

Campylobacter fetus immün yetmezliği olan hastalarda bağırsak dışı enfeksiyonların önemli bir etkenidir. Bu çalışmada miyelodisplastik sendromlu bir hastada C. fetus subsp. fetus'e bağlı bir bakteriyemi olgusu sunuldu. Miyelodisplastik sendrom tanısı olan 78 yaşında kadın hasta, solunum sıkıntısı ve göğüs ağrısı şikayeti ile acile kabul edildi. Hastaya pnömoni tanısı konuldu ve mikrobiyolojik testler için kan, boğaz ve idrar örnekleri alındı. Ampirik olarak trimetoprim-sulfametaksazol ve piperasilin-tazobaktam başlandı. Kan kültürlerinden C. fetus subsp. fetus izole edildi ve tedaviye klaritromisin eklendi. Hasta toplam 21 gün antibiyotik tedavisi aldı. Genel durumu düzelen hasta tekrarlayan kan kültürlerinde üreme olmaması üzerine taburcu edildi.Türkiye'de mevcut literatürde C. fetus enfeksiyonlarının insidansı düşüktür ve olgu raporları nadirdir. Bu bakteri ile oluşabilecek enfeksiyonlar klinik laboratuvarlarda göz ardı edilmemelidir.

Campylobacter fetus subsp. fetus bacteremia in a patient with myelodysplastic syndrome: A case report

Campylobacter fetus is an important pathogen of extra intestinal infections in patients with immunodeficiency. A case of Campylobacter fetus subsp. fetus bacteremia in a patient with myelodysplastic syndrome was presented in this study. A 78-year-old woman with myelodysplastic syndrome was admitted to the emergency due to chest pain and dyspnea. A diagnosis of pneumonia was made, and blood, throat, and urine samples were obtained for microbiological tests. Trimethoprim-sulfamethoxazole and piperacillin-tazobactam were empirically initiated. C. fetus subsp. fetus was isolated from blood cultures and clarithromycin was added. The patient responded an overall 21-day antimicrobial treatment. Because repeated blood cultures were negative, and her general condition improved, upon that she was discharged from the hospital.In conclusion, the incidence of C. fetus infections was low, and case reports are rare in current literature in Turkey. The infections can occur with these bacteria should not be overlooked in the clinical laboratory. J Microbiol Infect Dis 2014; 4(4): 165-167

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1. https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax. cgi?id=194. The last accessed date: 21.03.2014
2. Moolhuijzen PM, Lew Tabor AE, Wlodek BM, et al. Genomic analysis of Campylobacter fetus subspecies: identification of candidate virulence determinants and diagnostic assay targets. BMC Microbiology 2009; 9:86
3. Fernández Cruz A, Muñoz P, Mohedano R, et al. Campylobacter bacteremia: clinical characteristics, incidence, and outcome over 23 years. Medicine 2010; 89:319-330.
4. Zonios DI, Panayiotakopoulos GD, Kabletsas EO, et al. Campylobacter fetus bacteremia in a healthy individual: clinical and therapeutical implications. J Infect 2005; 51:329-332.
5. Clinical and Laboratory Standards Institute. Methods for Antimicrobial Dilution and Disk Susceptibility Testing of Infrequently Isolated or Fastidious Bacteria; Proposed Guideline. CLSI document M45-P. CLSI, Wayne, Pennsylvania, USA, 2005.
6. Ali A, Soares SC, Santos AR, et al. Campylobacter fetus subspecies: Comparative genomics and prediction of potential virulence targets. Gene 2012; 508:145-156.
7. Targan SR, Chow AW, Guze LB. Campylobacter fetus associated with pulmonary abscess and empyema. Chest 1977; 71:105-108.
8. Martínez Balzano C, Kohlitz PJ, Chaudhary P, Hegazy H. Campylobacter fetus bacteremia in a young healthy adult transmitted by khat chewing. J Infect 2013; 66:184-186.
9. Yao JD, Ng HM, Campbell I. Prosthetic hip joint infection due to Campylobacter fetus. J Clin Microbiol 1993; 31:3323-3324.
10. Yamashita K, Aoki Y, Hiroshima K. Pyogenic vertebral osteomyelitis caused by Campylobacter fetus subspecies fetus. A case report. Spine 1999; 24:582-584.
11. Barrio J, Castiella A, Gil I, et al. Spontaneous bacterial peritonitis by Campylobacter fetus in Budd-Chiari syndrome without liver cirrhosis. Liver1999; 19:69-70.
12. Takatsu M, Ichiyama S, Nada T, et al. Campylobacter fetus subsp. fetus cholecystitis in a patient with advanced hepatocellular carcinoma. Scand J Infect Dis 1997; 29:197-198.
13. Ledina D, Ivic I, Karanovic J, et al. Campylobacter fetus infection presenting with bacteremia and cellulitis in a 72-yearold man with an implanted pacemaker: a case report. J Med Case Rep 2012; 6:414.
14. Tatman Otkun M, Aydın Tutak G, Gülsen E, Ozgen Z. A Case of Bacteremia Due to Campylobacter fetus subsp. fetus and Importance of Gram Stain at Laboratory Diagnosis. Turk Hij Den Biyol Derg 2009;66:21-24.
15. Cypierre A, Denes E, Barraud O, et al. Campylobacter fetus infections. Med Mal Infect 2014; S0399-077X(14)00029-8. doi: 10.1016/j.medmal.2014.02.001.