Öz Invasive fungal infections occur in 5-59% of solid organ transplant recipients. Among fungal infections, Cryptococcus remains a significant opportunistic infection in solid organ transplant recipients. The incidence of cryptococcal infection in solid organ recipients was about 2.8 per 100 transplant recipients. Mortality rates in organ transplant recipients with cryptococcosis range from 15% to 20%.The type of primary immunosuppressive agents used in solid organ transplant recipients influences the predominant clinical manifestations of cryptococcosis. Patients who are receiving tacrolimus were significantly less likely to have central nervous system involvement and more likely to have skin, soft tissue and osteoarticular involvement than patients receiving non tacrolimus-based immunosuppressive agents We report a case of cutaneous Cryptococcus neoformans infection in 59 years old renal transplant recipient who underwent renal transplantation ten years ago. He was on immunosuppressant drugs like tacrolimus. High clinical suspicion will help in early diagnosis and treatment. J Microbiol Infect Dis 2019; 9(4):164-166.