Leman Kayaş, İlyas Yolbaş, Aydın Ece, Yavuz Kayaş, Halil Kocamaz

Causative agents and antibiotic susceptibilities in children with urinary tract infection

Anahtar Kelimeler:

-

Causative agents and antibiotic susceptibilities in children with urinary tract infection

Objectives: Nowadays, it has become more difficult treatment of the urinary tract infections because of developing high antibiotic resistance. The aim of this study was to investigate the most common causative microorganisms, their susceptibility and resistance to antibiotics in childhood urinary tract infections (UTI). Materials and methods: In this study, data belonging to urinary culture of 111 children with the diagnosis of UTI at Dicle University Medical School, Department of Pediatrics, throughout 1.5 years. Results: Of all cases 97 (87.4%) were female and 14(12.6%) were male. The most common complaints of children were dysuria, fever, flank pain and pollakiuria. Isolated microorganisms according to decreasing frequency were E.coli (75.7%), Klebsiella sp (7.2%), Proteus sp (6.3%) and Enterobacter sp (1.8%). The resistance rates against trimethoprim-sulfamethoxazole was 71.3%, ampicillin 82.4%, amoxicillin-clavulanate 54.7% and tetracycline 68.3%, and the least resistance rates were for ceftriaxone (16%) and amikacin (8.1%). Conclusion: In conclusion, the most common causative agent was E.coli and the highest resistance ratios were against trimethoprim-sulfamethoxazole, ampicillin and amoxicillin-clavulanate in children with UTI that presented in this study. Fewest ratio of resistance was found against amicasin and cephtriaxone.

Keywords:

Childhood, urinary tract infections, causative organisms, antibiotic sensitivity resistance,

PDF

___

Saatçi Ü. İdrar yolu enfeksiyonu. Çocuk Sağ ve Hast Derg 1994; 37: 461-477.
Hansson S, Jodal ULF. Urinary tract infection. In: Barratt TM, Avner ED, Harmon WE. (eds). Pediatric Nephrology. Lippin- cott Williams&Wilkins, Baltimore 1999; 835-850.
Şirin A, Emre S, Alpay H, Nayir A, Bilge I, Tanman F. Etiology of chronic renal failure in Turkish children. Pediatr Nephro1 1995; 9:549-552.
Mir S. Recurrent Urinary Tract Infection in Turkey: Epidemi- ology and prevalence. Annual Aegean Pediatric Nephrology Seminars, 16-17 May 1994, İzmir.
Jones KV, Asscher AW. Urinary tract infection and vesi- coureteral reflux. In: Edelmann CM. (eds). Pediatric Kidney Disease. Second edition. Volume II, Little Brown Company. Boston, Toronto, London 1992; 1943-91.
Günay T, Dallar Y, Tanyer G, Arıhan İ. Çocuklarda idrar yolu enfeksiyonları ve takibi: sık görülen mikroorganizmalar, anti- biyotiklere duyarlılıkları. Klinik Bilimler- Doktor 1999; 5: 238- 241.
Oğuz F, Sıdal M, Öngen B, Altınel Z. Üriner sistem enfeksiyon- lu çocuklarda trimethoprim/rsulfametoksazol, amoksisilin- klavunat ve sefaklor tedavisi sonuçlarının karşılaştırılması. İstanbul Çocuk Klin Derg 1994; 29: 174-180.
Ghiro L, Cracco AT, Sartor M, Comacchio S, Zacchello G, Amico RD. Retrospective study of children with acute pyelo- nephritis. Nephron 2002;90:8-15.
Hubrecht JM, Lontie M, Caudron M. The in vitro susceptibil- ity of urinary tract pathogens to mecillinam, compared with other antimicrobial agent: a multicenter study. Clin Microbiol Infect 2001; 7 : 70-75.
Kahlmeter G. The ecosens project: a prospective, multina- tional, multicenter epidemiological survey of the prevalence and antimicrobial susceptibility of urinary tract pathogens- interim report. J Antimicrob Chemother 2000; 46 : 15-22.
McLoughlin TG Jr, Joseph MM. Antibiotic resistance patterns of uropathogens in pediatric emergency department patients. Acad Emerg Med 2003; 10: 347-351.
Haller M, Brandis M, Berner R. Antibiotic resistance of uri- nary tract pathogens and rationale for empirical intravenous therapy. Pediatr Nephrol 2004; 19: 982-986.
Bouallegue O, Saidani M, Ben Mohamed S, Mzoughi R. Bac- teriologic features of urinary tract infections in children in the Sousse area, Tunisia. Tunis Med 2004; 82: 742-746.
Alpay H, Göknel Ö, Bilgen N, et al. Çocukluk çağı üriner sis- tem enfeksiyonlarında etken mikroorganizmalar ve antibiyo- tik duyarlılıkları. Ankem Derg 1995; 9: 118-123.
Tosun SY, Demirel MM, Ertan P, Aksu S. Çocuklara ait idrar örneklerinden izole edilen bakteriler ve antibiyotik duyarlılık- ları. T Klin Ped 2004; 13: 59-62.
Gonzales R. Urinary tract infections. In: Behrman RE, Klieg- man RM, ArvinA. (eds). Nelson Textbook of Pediatrics. 15th ed. WB Saunders Co, Philadelphia 1996; 1528-32.
Hacock GB. Investigation of urinary tract infections. Arch Dis Child 1986; 61: 1155-1158.
Sherbotie JR, Cosifeld D. Management of urinary tract infec- tions in children. Med Clin North Am 1991; 75: 327-338.
Pape L, Gunzer F, Ziesing S, Pape A, Offner G, Ehrich JH. Bacterial pathogens, resistance patterns and treatment op- tions in community acquired pediatric urinary tract infections. Klin Pediatr 2004; 216: 83-86.
Sakran W, Miron D, Halevy R, Colodner R, Smolkin V, Koren A. Community acquired urinary tract infection among hospi- talized children in northern Israel: pathogens, susceptibility patterns and urinary tract anomalies. Harefuah 2003; 142: 249-252.