Yoğun bakım ünitesinde ortalama platelet hacmi ve platelet dağılım hacminin mortaliteye etkisi

Giriş/Amaç: Bu çalışmada genel Yoğun Bakım Ünitesi’ndeki (YBÜ) hasta populasyonunda, MPV (ortalama platelet hacmi) ve PDW (platelet dağilim hacmi) parametrelerinin mortalite ile olan ilişkisini değerlendirmeyi amaçladık.Gereç ve Yöntem: Genel YBÜ’ de yatan 284 hasta retrospektif olarak analiz edildi. Hastaların ilk yatışlarında MPV ve PDW değerleri, ölmeden veya taburcu edilmeden önceki son MPV ve PDW değerleri, hastanede yatış süreleri ve yaşları kaydedildi.Bulgular: Hayatta kalan hasta grubunda MPV ve PDW değerleri arasında anlamlı fark yoktu. Benzer şekilde, ölen hastaların grubunda PDWFirst ve PDWLast değerleri arasında istatistiksel olarak anlamlı fark yoktu (p> 0.05). Bununla birlikte, ölen hastaların grubunda MPVLast değeri, MPVFirst değerlerine göre anlamlı olarak arttı (p <0.05). Mortalite ile ilişkili hastaların yaş, hastanede kalış süreleri, MPV ve PDW değerleri karşılaştırıldığında en önemli faktör MPVLast olarak bulundu.  Sonuç: Bu çalışma, ölen hastalarda MPV değerlerinin arttığını ve mortalite ile yakından ilişkili olduğunu göstermiştir.

Mean platelet volume and platelet distribution width as mortality predictors in ıntensive care unit

Background and Aim: This study aimed to determine the mean platelet volume (MPV) and platelet distribution width (PDW) values of intensive care patients, and show the relationship between these parameters and mortality. Material and Method: In the present study, 284 patients who were hospitalized in the intensive care unit were retrospectively analyzed. MPV and PDW values of the patients when they first hospitalized, their last MPV and PDW values before they died or were discharged, their ages and duration of hospitalization were recorded. Results: There was no significant difference between the MPV and PDW values in the group of the patients who survived. Similarly, there was no statistically significant difference between PDWFirst and PDWLast values in the group of the patients who died (p> 0.05). However, MPVLast value increased significantly compared to MPVFirst values (p <0.05) in the group of the patients who died. MPVLast was found to be the most important factor when the age, hospitalization period, MPV and PDW values of the patients, which are associated with mortality, were compared. Conclusion: This study showed that MPV values increased in the patients who died and that they were closely related to mortality.

___

  • 1. Nurden AT. Platelets, inflammation and tissue regeneration. Thromb Haemost 2011; 105(S 06), 13-33 (PMID: 21479340).
  • 2. McFadyen JD, Kaplan ZS. Platelets are not just for clots. Transfus Med Rev 2015; 29(2), 110-119 (PMID: 25680870)
  • 3. Lippi G, Pavesi F, Pipitone S. Evaluation of mean platelet volume with four hematological analyzers: harmonization is still an unresolved issue. Blood Coagul Fibrinolysis 2015; 26(2), 235-237 (PMID: 25255243).
  • 4. Budak YU, Polat M, Huysal K. The use of platelet indices, plateletcrit, mean platelet volume and platelet distribution width in emergency non-traumatic abdominal surgery: a systematic review. Biochem Med. 2016; 26(2), 178-193 (PMID: 27346963).
  • 5. Demirin H, Ozhan H, Ucgun T, et al. Normal range of mean platelet volume in healthy subjects: Insight from a large epidemiologic study. Thromb Res 2011; 128(4), 358-360 (PMID: 21620440).
  • 6. Larsen SB, Grove EL, Hvas AM, Kristensen SD. Platelet turnover in stable coronary artery disease—influence of thrombopoietin and low-grade inflammation. PloS one 2014; 9(1), e85566 (PMID: 24465602).
  • 7. Thompson CB, Eaton KA, Princiotta SM, Rushin CA, Valeri CR. Size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity, and function. Br J Haematol 1982; 50(3), 509-519 (PMID: 7066203).
  • 8. Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996; 7(2), 157-161 (PMID: 8735807).
  • 9. Choi DH, Kang SH, Song H. Mean platelet volume: a potential biomarker of the risk and prognosis of heart disease. Korean J Intern Med 2016; 31(6), 1009-1017 (PMID: 27776204).
  • 10. Gasparyan AY, Ayvazyan L, Mikhailidis PD, Kitas DG. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des 2011; 17(1), 47-58 (PMID: 21247392)
  • 11. Beyazit Y, Sayilir A, Torun S, et al. Mean platelet volume as an indicator of disease severity in patients with acute pancreatitis. Clin Res Hepatol Gastroenterol 2012; 36(2), 162-168 (PMID: 22088974).
  • 12. Sachdev R, Tiwari AK, Goel S, Raina V, Sethi M. Establishing biological reference intervals for novel platelet parameters (immature platelet fraction, high immature platelet fraction, platelet distribution width, platelet large cell ratio, platelet-X, plateletcrit, and platelet distribution width) and their correlations among each other. Indian J Pathol Microbiol 2014; 57(2), 231 (PMID: 24943755).
  • 13. Maluf CB, Barreto SM, Vidigal PG. Standardization and reference intervals of platelet volume indices: Insight from the Brazilian longitudinal study of adult health (ELSA-BRASIL). Platelets 2015; 26(5), 413-420 (PMID: 25101826).
  • 14. Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 2010; 14(1), 28 (PMID: 20411056)
  • 15. Rapsang AG, Shyam DC. Scoring systems in the intensive care unit: a compendium. Indian J Crit Care Med 2014; 18(4), 220 (PMID: 24872651).
  • 16. Zimmerman, J. E., Alzola, C., & Von Rueden, K. T.. The use of benchmarking to identify top performing critical care units: a preliminary assessment of their policies and practices. J Crit Care 2003; 18(2), 76-86.
  • 17. Maccariello, E. R., Valente, C., Nogueira, L., Ismael, M., Valença, R. V., Machado, J., Soares, M. Performance of six prognostic scores in critically ill patients receiving renal replacement therapy. Rev Bras Ter Intensiva 2008; 20(2), 115-123.
  • 18. Uysal N, Gündogdu N, Börekçi S, Dikensoy Ö, Bayram N, Uyar M, Mutlu GM. Prognosis of Patients in a Medical Intensive Care Unit of a Tertiary Care Centre. Yogun Bakim Dergisi 2010; 1(1), 1 (PMID: 28058366)
  • 19. Unal AU, Kostek O, Takir M, Caklili O, Uzunlulu M, Oguz A. Prognosis of patients in a medical intensive care unit. North Clin Istanb 2015; 2(3), 189 (PMID: 28058366)
  • 20. Castella X, Artigas A, Bion J, Kari A. A comparison of severity of illness scoring systems for intensive care unit patients: Results of a multicenter, multinational study. Crit Care Med 1995; 23(8), 1327-1335(PMID: 7634802).
  • 21. Le Gall JR, Lemeshow S, Saulnier F. A new simplified acute physiology score (SAPS II) based on a European/North American multicenter study. Jama 1993; 270(24), 2957-2963 (PMID: 8254858).
  • 22. Martin JF, Bath PMW, Burr ML. Influence of platelet size on outcome after myocardial infarction. The Lancet 1991; 338(8780), 1409-1411(PMID: 1683417).
  • 23. Mayda-Domaç F, Mısırlı H, Yılmaz M. Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic stroke. J Stroke Cerebrovasc Dis 2010 19(1), 66-72 (PMID: 20123229)
  • 24. Zhang Z, Xu X, Ni H, Deng H. Platelet indices are novel predictors of hospital mortality in intensive care unit patients. J Crit Care 2014; 29(5), 885. e 1-6 (PMID: 24895093).
  • 25. Sezgi C, Taylan M, Kaya H, et al. Alterations in platelet count and mean platelet volume as predictors of patient outcome in the respiratory intensive care unit. Clin Respir J 2015; 9(4), 403-408 (PMID: 24725778)
  • 26. Khandekar MM, Khurana AS, Deshmukh SD, Kakrani AL, Katdare AD, Inamdar AK. Platelet volume indices in patients with coronary artery disease and acute myocardial infarction: an Indian scenario. J Clin Pathol 2006; 59(2), 146-149 (PMID: 16443728).
  • 27. Lee JH, Park M, Han S, Hwang JJ, Park SH, Park SY. An increase in mean platelet volume during admission can predict the prognoses of patients with pneumonia in the intensive care unit: A retrospective study. PLoS one 2018; 11;13(12) (PMID: 30533065).
Journal of Health Sciences and Medicine-Cover
  • Yayın Aralığı: Yılda 6 Sayı
  • Başlangıç: 2018
  • Yayıncı: MediHealth Academy Yayıncılık
Sayıdaki Diğer Makaleler

Kemik metastazlı olgularda palyatif radyoterapi uygulamalarının retrospektif değerlendirmesi: tek merkez deneyimi

Fatih GÖKSEL

Kırım Kongo kanamalı ateş ile herpes zoster oftalmikus birlikteliği

Hüseyin ESMER, Çiğdem ATAMAN HATİPOĞLU, Salih CESUR, Kader ARSLAN, Sami KINIKLI

Doğurganlık çağındaki kadınlarda toksoplazma, rubella ve sitomegalovirüs seroprevalansının araştırılması

Fatih TEMOÇİN, Hatice KÖSE

Myomektomi uygulanan kadınlarda vücut kitle indeksi ile klinik parametreler arasındaki ilişkinin değerlendirilmesi

Buğra ÇOŞKUN, Ali İrfan GÜZEL, Bora ÇOŞKUN, Demet KOKANALI, Coşkun ŞİMŞİR, Melike DOĞANAY

Hemodiyaliz hastasında asemptomatik retroperitoneal kanama: olgu sunumu

Mehmet Emin DEMİR

HIV pozitif hastalarda HHV-6 prevalansı ve varyant tiplerinin belirlenmesi

Gülnur TARHAN, Neziha YILMAZ, Salih CESUR

Serum IGF-1 düzeyleri akut miyokard infarktüsü sonrası gerçekten azalır mı ve sol ventrikül disfonksiyonu ile ilişkili midir?

Yücel YILMAZ, Fatih TANRIVERDİ, Mustafa DURAN, Mustafa ALTAY, Namık Kemal ERYOL

Yoğun bakım ünitesinde ortalama platelet hacmi ve platelet dağılım hacminin mortaliteye etkisi

İşın GENÇAY, Ünase BÜYÜKKOÇAK, Gökay ATEŞ, Osman ÇAĞLAYAN

Sigara kulanımının klopidogrel tedavisi alan hastalarda P2Y12 trombosit fonksiyon testi ile değerlendirilen trombosit reaktivitesi üzerine etkisi

Taner SARAK, Ersin SARİCAM, Abbas TANER

Perinatoloji kliniğine başvuran fetal anomalileri bulunan gebeliklerin değerlendirilmesi

Tuğba KARABULUT, Fatma Devran BILDIRCIN, Pervin KARLI, Ayşe ÖZDEMİR