Yüksek Yağlı Diyetle Beslenen Ratlarda Egzersizin Serum Resistin ve Leptin Değerlerine Etkisi

Amaç: Bu çalışma, yüksek yağlı diyetle beslenen ratlarda egzersizin serum resistin ve leptin değerlerine nasıl bir etkisinin olacağını araştırmak için yapıldı. Gereç ve Yöntem: Çalışmada 24 adet Wistar albino ırkı erkek rat kullanıldı. Her grupta 6 adet rat olacak şekilde rastgele 4 gruba ayrıldı. Gruplar kontrol grubu (K), egzersiz grubu (E), yüksek yağlı diyet (YYD) grubu ve yüksek yağlı diyet + egzersiz (YYDE) Grubu olarak belirlendi. Bulgular: Yapılan bu araştırmada elde edilen bulgular istatiksel olarak değerlendirildiğinde K, E ve YYDE gruplarında resistin değerlerinin benzer olduğu, YYD grubunda ise diğer gruplara göre yüksek olduğu tespit edilmiştir. Yüksek yağlı diyet ile artan resistin değerinin egzersiz ile düştüğü görülmüştür. Leptin seviyeleri açısından değerlendirildiğinde K ve E grubu benzerlik gösterirken, YYD ve YYDE grupları da birbiri ile benzerlik göstermektedir. Yüksek yağlı diyet ile oldukça artan leptin seviyesini egzersiz bir miktar düşürse de, istatistiksel açıdan anlamlı bulunmamıştır. Sonuç: Yüksek yağlı diyet ile beslenmenin serum resistin ve leptin düzeylerinde artışa sebep olduğu, egzersizin resistin değerlerinde anlamlı bir düşüş sağladığı fakat leptin düzeylerinde etkili olmadığı tespit edilmiştir.

Anahtar Kelimeler:

Resistin, Leptin, Exercise, High-fat diet

The Effect of Exercise on Serum Resistin and Leptin Values in Rats Fed with a High Fat Diet

Aim: This study was performed to investigate the effect of exercise on serum resistin and leptin values in rats fed with a high-fat diet. Material and Method: 24 Wistar albino male rats were used in the study. They were randomly divided into 4 groups, with 6 rats in each group. The groups were determined as the control group (C), exercise group (E), high-fat diet (HFD) group, and high-fat diet + exercise (HFDE) Group. Results: When the findings obtained in this study were evaluated statistically, it was determined that the resistin values were similar in the C, E and HFDE groups, and higher in the HFD group compared to the other groups. It was observed that resistin value increased with high-fat diet and decreased with exercise. When evaluated in terms of leptin levels, the C and E groups showed similarity, while the HFD and HFDE groups showed similarity with each other. Although exercise decreased the leptin level, which was highly increased with a high-fat diet, it was not statistically significant. Conclusion: It has been determined that feeding with a high-fat diet causes an increase in serum resistin and leptin levels, and exercise provides a significant decrease in resistin values, but is not effective in leptin levels.

Keywords:

Resistin, Leptin, Exercise, High-fat diet,

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