Ailesel Granüloma Anülare

Granüloma anülare benin, asemptomatik, nispeten yaygın, sıklıkla kendi kendini sınırlayan, hem çocukları hem erişkinleri etkileyebilen derinin kronik granülomatöz hastalığıdır. Primer deri lezyonu çevreye doğru yayılan anüler şekilli grup yapmış deri renginde veya eritematöz papüller şeklindedir. En sık görülen iki tipinden birisi el ve ayak lateral veya dorsallerinde yerleşen lokalize tip diğeri lezyonların yaygın olduğu jeneralize tiptir. Nadiren ailesel granüloma anülare olguları bildirilmiştir. Burada klinik ve histopatolojik bulgularla granüloma anülare tanısı alan anüler papül ve plakları olan iki kız kardeş sunulmuştur.    
Anahtar Kelimeler:

Granüloma anülare; ailesel

Familial Granuloma Annulare

Granuloma annulare is a benign, asymptomatic,  relatively common, often self-limited chronic granulomatos disorder of the skin that can affect both children and adults. The primary skin lesion usually is grouped papules in an enlarging annular shape, with color ranging from flesh-colored to erythematous.  The two most common types of granuloma annulare are localized, which typically is found on the lateral or dorsal surfaces of the hands and feet; and disseminated, which is widespread. Rarely, familial cases of granuloma annulare has been reported. Herein, we report two sisters with annular papules and plaques  diagnosed as granuloma annulare with the clinical and pathological findings.  Key words: Granuloma annulare, familial occurence

___

  • -Fox TC. Ringed eruption of the fingers. Br J Dermatol 1895; 7:91.
  • -Dahl MV. Granuloma annulare. Fitzpatrizk’s Dermatology in General Medicine. Ed. Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA,Katz SK. 6. bask›. Newyork, McGraw-Hill 2003;980-4
  • - Kovich O, Burgin S. Generalized granuloma annulare. Dermatol Online J. 2005 Dec 30;11(4):23.
  • -Mutasim DF, Bridges AG: Patch granuloma annulare: clinicopathologic study of 6 patients. J Am Acad Dermatol 2000;42:417-21
  • -Park JY, Park JE, Kim YC. Generalized granuloma annulare possibly associated with acute Epstein-Barr virus infection. Eur J Dermatol. 2011 Sep-Oct;21(5):788-9.
  • -Chiu ML,Tang MB. Generalized granuloma annulare associated with gastrointestinal stromal tumour: case report and review of clinicalfeatures and management. Clin. Exp Dermatol 2008;33:469-71.
  • -Friedman SJ, Winkelmann RK. Familial granuloma annulare. Report of two cases and review of the literature. J Am Acad Dermatol 1987; 16:600.
  • -Rook A, Davis R, Stevanovic D. Familial granuloma annulare; report of two cases, with observations on the incidence of the disease in Britain. Acta Derm Venereol 1957; 37:160.
  • -Suite M, Jankey N. Familial granuloma annulare. Int J Dermatol. 1992 Nov;31(11):818.
  • -Friedman-Birnbaum R, Haim S, Gideone O, Barzilai A. Histocompatibility antigens in granuloma annulare. Comparative study of the generalized and localized types. Br J Dermatol 1978; 98:425.
  • -Friedman-Birnbaum R, Gideoni O, Bergman R, Pollack S. A study of HLA antigen association in localized and generalized granuloma annulare. Br J Dermatol 1986; 115:329.
Journal of Contemporary Medicine-Cover
  • Yayın Aralığı: Yılda 6 Sayı
  • Başlangıç: 2011
  • Yayıncı: Rabia YILMAZ