Üroonkolojik cerrahide rejyonel ve genel anestezinin immün sistem üzerine etkilerinin serum sitokinleri aracılığı ile karşılaştırılması

Amaç: Bu çalışmada cerrahi geçiren ürolojik kanser hastalarında genel anestezi ve spinal anestezi yöntemlerininimmün sistem üzerine olan etkileri serum interlökin-2 (IL- 2), İnterlökin-4 (IL-4), İnterlökin-6 (IL-6) aracılığı ile karşılaştırılması amaçlandı.Yöntemler: Çalışmaya üroonkolojik cerrahi geçirecek, ASA I-II, 18-60 yaş arasında spinal veya genel anestezi uygulanacak 44 hasta dahil edildi. Grupların kalp atım hızı, ortalama arteriyel basınç değerleri ve demografik özellikleri kaydedildi. Preoperatif ve postoperatif 6. saattevenöz kan örnekleri alınarak IL-2, IL-4 ve IL-6 düzeyleritespit edildi.Bulgular: Gruplar arası kalp atım hızı ve ortalama arteriyel basınç değerleri arasında anlamlı bir farklılığa rastlanmadı. Preoperatif IL-2, IL-4, IL-6 ve postoperatif IL-2, IL-4seviyeleri arasında anlamlı fark bulunmazken, postoperatif IL-6 seviyesi genel anestezi grubunda spinal anestezi grubuna göre anlamlı yüksek bulundu (p

Comparison of the effects of regional and general anesthesia on the immune system via cytokines in urooncologic surgery

Objectives: In this study, it was aimed to compare effects of general anesthesia and spinal anesthesia on the immune system via serum cytokines interleukine 2 (IL-2), interleukine 4 (IL4), interleukine 6 (IL-6) in urologic cancer patients. Methods: Forty-four, ASA physical status I–II patient,who were scheduled for urooncologic surgery with spinal or general anesthesia enrolled to the study. Demographic parameters, heart rate and mean blood pressure values were recorded. Venous blood samples were taken at preoperative period and postoperatively 6th hours to determine IL-2, IL-4 and IL-6 levels. Results: There was no statistical significance between groups among heart rate and mean blood pressure values. There were no significant difference in preoperative IL-2, IL-4, IL-6 and postoperative IL-2, IL-4 levels between groups, however postoperative IL-6 levels were significantly increased in general anesthesia group compared with spinal anesthesia group (p

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