Uğur UZUN, Tolga ERGÖNENÇ, Gülşen BİCAN, Jalan ŞERBETÇİGİL, Ali DİRİK

Comparison of the efficacy of esmolol and lidocaine in the control of hemodynamic response associated with intubation: A randomized controlled trial

Amaç: Bu randomize çalışmanın amacı endotrakeal entübasyonun neden olduğu hemodinamik yanıtın kontolünde esmolol ve lidokainin etkilerini karşılaştırmayı amaçlamaktır. Yöntemler: Bu çalışmaya ASA I-II olan 19 ve 76 yaşlarıarasında 40 hasta dâhil edildi. Rastgele olarak iki grubunaayrıldı. Grup E’ ye (n=20) 1,5 mg/kg esmolol, Grup L’ye (n=20) 1.5 mg/kg %2 lidokain i.v bolus olarak 30 saniyede anestezist tarafından uygulandı. Tüm hastalara aynıanestezi tekniği uygulandı. Sistolik kan basıncı (SKB), diastolik kan basıncı (DKB) ve ortalama kan basınçları (OKB) ile kalp atım hızı için belirlenen zamanlarda ölçüm-ler yapılarak kaydedildi. Bu ölçümler ve daha sonra yapılan değerlendirmeler, hangi ilacın uygulandığını bilmeyen bir anestezist tarafından gerçekleştirildi. Bulgular: Gruplar arasında demografik veriler açısından fark bulunmadı (p>0.05). Her iki grupta da çalışma ilacının uygulanmasıyla kalp atım hızı, sistolik kan basıncı, diyastolik kan basıncı ve ortalama kan basıncı düzeylerininin kontrol değerlerine göre azaldığını, bu azalmanın Grup E’ de daha belirgin olduğunu ve Grup L’ ye göre düşük bulundu. Grup L’ nin 1,5 ve 7. dakika SKB değerleri Grup E’ ye göre daha yüksek bulundu (p

Entübasyona bağlı hemodinamik yanıtın kontrolünde esmolol ve lidokainin etkinliğinin karşılaştırılması: Randomize kontrollü çalışma

Objectives: The purpose of this randomized study is tocompare the effects of esmolol and lidocaine in the control of hemodynamic response caused by endotrachealintubation.Methods: In this study, 40 patients with ASA I-II physicalstatus and between the ages of 19 and 76 were includedand randomly divided into two groups. In the Group E (n =20), iv bolus injection of 1.5 mg/kg esmolol, in the GroupL (n = 20), iv bolus injection of 1.5 mg/kg 2% lidocainewere given with iv bolus injection in 30 seconds. All patients received the same anesthetic technique. Systolicblood pressure (SBP), diastolic blood pressure (DBP)and mean blood pressure (MBP) and heart rate measurements were done at specified times and recorded. Records were assessed by an anesthesiologist blinded towhich drug is applied.Results: There was no difference between the groups in demographic data (p>0.05). In both groups, with the implementation of the study drug, systolic blood pressure, diastolic blood pressure and mean arterial blood pressure decreased compared to controls, this reduction was lower in Group E than Group L. In Group L, SBP values of 1.5 and 7 minutes were higher than Group E (p

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