Ayhan ÖZTÜRK, Hatice GÜMÜŞ, Süber DİKİCİ, Gülşen KOCAMAN

Tekrarlayan Guillain-Barré sendromu ve idiyopatik trombositopenik purpura birlikteliği

Guillain-Barré sendromu (GBS), genellikle hızlı ve ilerleyi- ci giden, asendan simetrik kuvvet kaybı ve arefleksi ile ka- rakterize akut enflamatuar polinradikülonöropatidir. Klinik tablonun gelişim mekanizması tam olarak bilinmemekle birlikte immun faktörler suçlanmaktadır. GBS geçiren has- taların %1-10’unda tekrarlama ihtimali vardır. İdiyopatik trombositopenik purpura (İTP), ortadan şiddetliye kadar değişebilen trombositopeninin eşlik ettiği edinsel sistemik bir hastalıktır. 12 yıldır İTP tanısıyla takip edilirken, 2 yıl arayla GBS geçiren olgu nadir gözlendiği için sunulacak- tır.

Recurrent Guillain-Barré syndrome associated with idiopathic thrombocytopenic purpura

Guillain-Barré syndrome (GBS) usually present with acute inflammatory polyradiculoneuropathy having clinical fea- tures of rapid and progressive weakness at the limbs, symmetric decrease or loss of tendon reflexes. The exact mechanism of clinical picture is not well known but im- mune factors are blamed. Patients having GBS have an recurrence rate ranging between 1% and 10%. Idiopathic thrombocytopenic purpura (ITP) is an acquired systemic disease presented with mild to severe thrombocytopenia. The patient who followed with ITP diagnosis for 12 years underwent 2 times GBS attacks within 2-year interval. We would like to present this case due to rare association of ITP diagnosis & GBS attacks. J Clin Exp Invest 2012; 3(2): 284-286

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1. Winer JB. Guillain-Barré Syndrome. J Clin Pathol Mol Pathol 2001;54(2):381-5.
2. Hughes RAC, Rees JH. Clinical and epidemiologic features of Guillain-Barré syndrome.Clin Infect Dis 1997;176(Suppl 2):S92-S98.
3. Pithadia AB, Kakadia N. Guillain-Barré syndrome (GBS). Pharmacol Rep 2010;62(2):220-32.
4. Baba M, Matsunaga M, Narita S, Liu H. Recurrent Guillain-Barré syndrome in Japan. Intern Med 1995;34: 1015-8.
5. Combes A, Goulon M. Recurrence of Guillain-Barré syndrome. Ann Med Interne (Paris) 1992; 143: 515-8.
6. Kuitwaard K, van Koningsveld R, Ruts L, Jacobs BC, van Doorn PA. Recurrent Guillain-Barré syndrome. J Neurol Neurosurg Psychiatry 2009;80(1):56-9.
7. Gernsheimer T. Chronic idiopathic thrombocytopenic purpura: Mechanisms of Pathogenesis. Oncologist 2009;14(1):12–21
8. Khaldi F, Larnaout A, Miladi N, Bennaceur B. Guillain Barré syndrome and idiopathic thrombocytopenic pur- pura. Can J Neurol Sci 1990;17(1):95-6.
9. Combarros O, Calleja J, Hernández L, Polo JM, Berciano J. Guillain-Barré syndrome associated with idiopathic thrombocytopenic purpura. J Neurol Neurosurg Psychiatry 1991;54(7):654-5.