Eşref AKIL, Mehmet Ufuk ALUÇLU, Sefer VAROL, Hatice YÜKSEL, Adalet ARIKANOĞLU, Yavuz YÜCEL, Mehmet Uğur ÇEVİK

Serum levels of prolidase and ischemia modified albumin in patients with multiple sclerosis

Objectives: Increased levels of free radicals and oxidant molecules and decreased levels of antioxidant molecules have been defined in patients with multiple sclerosis (MS). Ischemia-modified albumin (IMA) levels have been advocated as a biomarker for evaluating the oxidative stress status. The aim of this study was to investigate the relationship between oxidative stress and MS. Materials and methods: We compared serum ischemia modified albumin levels and prolidase activity of 42 patients with MS (30 female, 12 male) and 30 age-matched healthy controls (21 female, 9 male). Results: Ischemia modified albumin levels of MS patients (73,07±26,53 ng/mL) were significantly higher than those of controls (60,18±18,01 ng/mL) (p=0.024). However, there were no significant differences in prolidase levels between patients and healthy controls (p=0.856). Conclusions: Increased ischemia modified albumin levels, supports the role of oxidative stress in patients with multiple sclerosis.

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