Kadir Serkan YALÇIN, Ali KOŞAR, Derya AKDENİZ, ŞAHİN Özlem BALCIK, Ümit AKYILDIZ, Sonay GÜVEN, Esra ATICI

Kronik lenfositik lösemi- mantle hücreli lenfoma transformasyonu: Bir olgu sunumu

Kronik lenfositik lösemi (KLL) morfolojik olarak B tip lenfositlerin artışıyla karakterize klonal lenfoproliferatif bir hastalıktır. KLL hastalarında ateş, kilo kaybı, sitopeni, klinik kötüleşme ve tedaviye direnç Richter sendromu gelişimini düşündürür. Richter transformasyonu genelde diffüz büyük hücreli lenfomaya dönüşüm olarak izlense de diğer lenfoma tiplerine transformasyonlar daha az sıklıkla gözlenebilmektedir. Sunacağımız vakada; kronik lenfositik lösemi tanısıyla izlenmekte olan bir hastada nadir olan mantle hücreli lenfoma transformasyonu gözlemledik.

Transformation of chronic lymphocytic leukemia to mantle cell iymphoma: A case report

Chronic lymphocytic leukemia (CLL) is a clonal lymphoproliferative disease characterized by clonal expansion of B lymphocytes. Richter Transformation (RT) must be considered if CLL patient had fever, weight loss, cytopenia and resistance to standard therapy. Despite CLL usually transforms to diffuse large cell lymphoma, some rare lymphomas may occur as RT such as Hodgkin variants, lymphoblastic lymphoma nad mantle cell lymphoma. Here, we report a case of Mantle cell lymphoma has become secondary to chronic lymphocytic leukemia due to its being a rare entity.

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