Effect of imaging time on post stress left ventricular ejection fraction and volume measures by gated myocardial perfusion single photon emission computed tomography

Amaç: Efor sonrası sol ventrikül ejeksiyon fraksiyonu (LVEF) ve sol ventrikül volüm değerlerinin koroner arter hastalığı bulunan hastalardaki kardiyak ölüm tahmininde katkısı vardır. Bu çalışmada, efor sonrası görüntüleme zamanının Quantitative Gated SPECT (QGS-Cedars-Sinai) programı ile hesaplanan efor sonrası LVEF, end-diastolik volüm (EDV) ve end-sistolik volüm (ESV) üzerine etkisini araştırmayı amaçladık. Hastalar ve yöntem: Bu çalışma 2008 ve 2009 yıllarında Elazığ Eğitim ve Araştırma Hastanesi Nükleer Tıp Birimine göğüs ağrısı nedeniyle Kardiyoloji Kliniğinden gönderilen 36 hasta üzerinde yapıldı. Tüm hastalara efor esnasında yapılan 99mTc-Mibi enjeksiyonunu takiben 20. ve 40. dakikalarda EKG-gated (8-bin frame modunda) miyokard perfüzyon SPECT sintigrafisi uygulandı. Kardiyak kantifikasyon yazılımı olan QGS programı kullanılarak LVEF, EDV ve ESV hesaplandı. İlk ve ikinci görüntülemelerden elde edilen LVEF, EDV ve ESV değerleri istatistiksel olarak birbirleri ile karşılaştırıldı.Bulgular: İlk ve ikinci görüntülemelerden elde edilen LVEF, EDV ve ESV değerleri arasında istatistiksel olarak anlamlı farklılık bulunmadı (p>0.05).Sonuç: Efor sonrası sol ventrikül fonksiyon parametreleri koroner arter hastalığı bulunan hastalardaki prognoz değerlendirmesinde önemlidir. Efor bitiminden 20-40 dakika sonra yapılan miyokard perfüzyon SPECT sintigrafisi efor sonrası LVEF, EDV ve ESV değerleri açısından tekrarlanabilir değerler vermektedir.

Görüntüleme zamanının gated miyokard perfüzyon tek foton emisyon bilgisayarlı tomografisi ile ölçülen sol ventrikül ejeksiyon fraksiyonu ve hacimleri üzerine etkisi

Objectives: Post-stress left ventricular ejection fraction (LVEF) and LV volumes have incremental value in predicting cardiac death (CD) in patients with coronary artery disease. In this study, we aimed to investigate the effect of imaging time after exercise on post-stress LVEF, end-diastolic volume (EDV) and end-systolic volume (ESV) calculated by cardiac quantification software program called Quantitative Gated SPECT (QGS-Cedars-Sinai).Materials and methods: This study was consisted of 36 patient referred to Nuclear Medicine Department from Cardiology Clinics because of chest pain in ‘Elazig Research and Training Hospital’ in 2008-2009. In all patients, ECG Gated (8-bin frame mode) myocardial perfusion SPECT scintigraphy was performed 20 and 40 min later following 99mTc-Mibi injection during exercise. By means of the cardiac quantification software program called Quantitative Gated SPECT (QGS-Cedars-Sinai); LVEF, EDV and ESV were calculated. LVEF, EDV and ESV values obtained from initial and second acquisition were compared statistically.Results: There was no statistically significant difference between post-stress LVEF, EDV and ESV measures of initial and second acquisition (p>0.05). Conclusion: Left ventricular functional parameters after exercise are important for assess prognosis in patients with CAD. Post-stress LVEF, EDV and ESV measured on gated myocardial perfusion SPECT images within 20-40 min after completion of exercise give reproducible information.

___

  • 1. Tout DA, Rogers A, Van Aswegen A, Underwood SR. Left ventricular function parameters obtained from gated myocardial perfusion SPECT imaging: a comparison of two data processing systems. Nucl Med Commun 2005;26:103-7.
  • 2. Lavender FM, Meades RT, Al-Nahhas A, Nijran KS. Factors affecting the measurement of left ventricular ejection fraction in myocardial perfusion imaging. Nucl Med Commun 2009;30:350-5.
  • 3. Ioannidis JPA, Trikalinos TA, Danias PG. Electrocardiogram-gated single-photon emission computed tomography versus cardiac magnetic resonance imaging for the assessment of left Ventricular volumes and ejection fraction. JACC 2002;39:2059–68.
  • 4. Faber TL, Vansant JP, Pettigrew RI, et al. Evaluation of left ventricular endocardial volumes and ejection fractions computed from gated perfusion SPECT with magnetic imaging: comparison of two methods. J Nucl Cardiol 2001;8:645–51.
  • 5. Vaduganathan P, He Z-X, Vick GW, Manmarian JJ, Verani MS. Evaluation of left ventricular wall motion, volumes, and ejection fraction by gated myocardial tomography with technetium 99mlabeled tetrofosmin: a comparison with cine magnetic resonance imaging. J Nucl Cardiol 1998;6:3–10.
  • 6. Sharir T, Germano G, Kavanagh PB, et al. Incremental prognostic value of post-stress left ventricular ejection fraction and volume by gated myocardial perfusion single photon emission computed tomography. Circulation 1999;100:1035-42.
  • 7. Hachamovitch R, Berman DS, Shaw LJ, et al. Incremental prognostic value of myocardial perfusion single photon emission computed tomography for the prediction of cardiac death. Ciculation 1998;97:535–543.
  • 8. Usui Y, Chikamori T, Nakajima K, Hida S, Yamashina A, Nishimura T. Prognostic value of post-ischemic stunning as assessed by gated myocardial perfusion single-photon emission computed tomography: a subanalysis of the J-ACCESS study. Circ J 2010;74:1591-9.
  • 9. EANM/ESC procedural guidelines for myocardial perfusion imaging in nuclear cardiology (2005).
  • 10. SNM procedure guideline for myocardial perfusion imaging 3.3 (2008).
  • 11. Lynne LJ, Facc SA, Verdesca WY, et al. Postischemic Stunning Can Affect Left Ventricular Ejection Fraction and Regional Wall Motion on Post-Stress Gated Sestamibi Tomograms. J Am Coll Cardiol 1997;30:1641–8.
  • 12. Sharir T, Germano G, Kang X, et al. Prediction of myocardial infarction versus cardiac death by gated myocardial perfusion SPECT: risk stratification by the amount of stress-induced ischemia and the poststress ejection fraction. J Nucl Med 2001;42:831–837.
  • 13. Denollet J, Brutsaert DL. Personality, disease severity, and the risk of long-term cardiac events in patients with a decreased ejection fraction after myocardial infarction. Circulation 1998;97:167-173.
  • 14. Ababneh AA, Sciacca RR, Kim B, Bergmann SR. Normal limits for left ventricular ejection fraction and volumes estimated with gated myocardial perfusion imaging in patients with normal exercise test results: Influence of tracer, gender, and acquisition camera. J Nucl Cardiol 2000;7:661-8.
  • 15. Borges-Neto S, Javaid A, Shaw LK, et al. Poststress measurements of left ventricular function with gated perfusion SPECT: comparison with resting measurements by using a same-day perfusion-function protocol. Radiology 2000;215:529-33.
  • 16. Rozanski A, Elkayam U, Berman DS, Diamond GA, Prause J, Swan HJC. Improvement of resting myocardial asynergy with cessation of upright bicycle exercise. Circulation 1983;67:529 –35.
  • 17. Nixon JV, Brown CN, Smitherman TC. Identification of transient and persistent segmental wall motion abnormalities in patients with unstable angina by two-dimensional echocardiography. Circulation 1982;65:1497–503.
  • 18. Rozanski A, Berman D, Gray R, et al. Preoperative prediction of reversible myocardial asynergy by postexercise radionuclide ventriculography. N Engl J Med 1982;307:212– 6.
  • 19. Ambrosio G, Betocchi S, Pace L, et al. Prolonged impairment of regional contractile function after resolution of exercise-induced angina: evidence of myocardial stunning in patients with coronary artery disease. Circulation 1996;94:2455– 63.
  • 20. Robertson S, Feigenbaum H, Armstong WF, Dillon JC, O’Donnell J, McHenry PW. Exercise echocardiography: a clinically practical addition in the evaluation of coronary artery disease. J Am Coll Cardiol 1983;2:1085–91.
  • 21. Katz A, Force T, Folland E, Aebischer N, Sharma S, Parisi A. Echocardiographic assessment of ventricular systolic function. In: Marcus ML and Braunwald E, editors. Marcus Cardiac Imaging: a Companion to Braunwald’s Heart Disease. Philadelphia: WB Saunders, 1996:297–324.
Journal of Clinical and Experimental Investigations-Cover
  • Başlangıç: 2010
  • Yayıncı: Sağlık Araştırmaları Derneği
Sayıdaki Diğer Makaleler

Is end-stage renal disease always symptomatic?

Rabia ALKAN, Şahin Özlem BALÇIK, Yeter BAYRAM, Ebru UZ, Burak UZ

Effectiveness of oral zinc sulphate, oral methotrexate and their combination in the treatment of psoriasis

Jawed H. AHMED, Saad Raheem ABD, Khalil I.Al-HAMDI

İleri derece yaşlı hastada mini doz bupivakain ile spinal anestezi

Adnan TÜFEK, Halit BAYKAN, Feyzi ÇELİK, Vildan TEMEL, Baysal Zeynep YILDIRIM, Ölmez Gönül KAVAK, Haktan KARAMAN

Kadınlarda cinsel fonksiyon bozukluklarına güncel yaklaşım

Levend ÖZKAN, Abdulkadir TEPELER, Hikmet YAŞAR

Endotrakeal tüp kafının doğru basınçta şişirilmesinde anestezistin deneyimi önemli mi?

Hekimoğlu Sevtap ŞAHİN, Cavidan ARAR, Alkin ÇOLAK, Işıl GÜNDAY, Ali SÖKER, Nesrin TURAN

Effect of imaging time on post stress left ventricular ejection fraction and volume measures by gated myocardial perfusion single photon emission computed tomography

Zuhal ARITÜRK, Ebru TEKBAŞ, Zeki DOSTBİL, Habib ÇİL, Bekir TAŞDEMİR, Mehmet Ali ELBEY

Hemşirelerin hizmet içi uyum eğitimine ilişkin görüşleri

Çiğdem ÖZDEMİR, Aysun DOĞAN, Yeter KIRLANGIÇ, Gül PINAR

Celiac disease presenting with extraintestinal manifestations

Şule BİLEN, Memet ASLANYAVRUSU, Aylin BOLAT, Fikri AK

Up to which limit can one survive with iron deficiency anemia?

Mehmet VURAL, Hakan BÜYÜKHATİPOĞLU

The effects of iron deficiency anemia on the thyroid functions

Erdem GÖKDENİZ, İmdat DİLEK, Cengiz DEMİR