Derin ven trombozu ile başvuran bir akut miyeloid lösemi olgusu

Çocuklarda görülen venöz tromboz çoğunlukla kateterizasyon, enfeksiyöz hastalıklar, kalıtsal trombofili ve metabolik hastalıklar gibi altta yatan bir risk faktörü ile ilişkilidir. Kanser çocukluk çağında görülen primer venöz trombozların önemli bir nedenidir ve çocukluk çağı venöz tromboz olgularının beşte birinden sorumludur. Bu yazıda ilk başvuru bulgusu derin ven trombozu olan ve takibinde akut myeloid lösemi (AML) tanısı konulan 13 yaşında kız hasta sunulmuştur.

A case of acute myeloid leukemia presenting with deep venous thrombosis

Deep venous thrombosis is mostly associated with an underlying risk factor such as venous catheter, infectious diseases, hereditary thrombophilia and metabolic diseases. Cancer is one of the most common primary disorders in pediatric venous thrombosis, accounting for one-fifth of children with thrombotic events. Here we report a 13-year-old female patient who is diagnosed as deep vein thrombosis due to acute myeloid leukemia.

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  • 1. Van Ommen CH, Heijboer H, Buller HR, Hirasing RA, Heijmans HS, Peters M. Venous thromboembolism in childhood: a prospective two-year registry in The Netherlands. J Pediatr 2001;139: 676-681.
  • 2. Revel-Vilk S, Massicotte P. Thromboembolic diseases of childhood. Blood Reviews 2003;17:1-6.
  • 3. Kuhle S, Massicotte P, Chan A, et al. Systemic thromboembolism in children. Thromb Haemost 2004;92:722-728.
  • 4. Bajzar L, Chan AK, Massicotte MP, et al. Thrombosis in children with malignancy. Curr Opin Pediatr 2006;18:1-9.
  • 5. Gorczyca W. Flow cytometry immunophenotypic characteristics of monocytic population in acute monocytic leukemia (AML-M5), acute myelomonocytic leukemia (AML-M4), and chronic myelomonocytic leukemia (CMML). Methods Cell Biol 2004;75:665–677.
  • 6. Andrew M, David M, Adams M, et al. Venous thromboembolic complications (VTE) in children: first analyses of the Canadian Registry of VTE. Blood 1994;83:1251–1257.
  • 7. Parasuraman S, Goldhaber SZ. Venous thromboembolism in children. Circulation 2006;113:12-16.
  • 8. Göttl NU, Kenet G, Mitchell LG. Thrombosis in childhood acute lymphoblastic leukaemia: epidemiology, etiology, diagnosis, prevention and treatment. Best Practice&Research Clinical Haematology 2009;22:103-114.
  • 9. Ku GH, White RH, Chew HK, et al. Venous thromboembolism in patients with acute leukemia: incidence, risk factors, and effect on survival. Blood 2009;113:3911-3917.
  • 10. Sutherland DE, Weitz IC, Liebman HA. Thromboembolic complications of cancer: epidemiology, pathogenesis, diagnosis and treatment. Am J Hematol 2003;72:43-52.
  • 11. Celkan T, Apak H, Özkan A, et al. Hastanede yatan çocuklarda saptanan tromboz etiyolojisi. Türk Pediatri Arşivi 2004;39:65-67.