Mehmet AŞIK, Kubilay UKİNÇ, Hacer ŞEN, Erdem AKBAL, Fahri GÜNEŞ, Emine BİNNETOĞLU, Şengül ÖZÇELİK, Burak ALTUN

Aşikar ve subklinik hipotiroidili hastalarda karotis arter intima media kalınlığı ve nötrofil lenfosit oranı

Amaç: Hipotiroidizmin ister aşikar ister subklinik olsun kardiyovasküler sistem üzerine çeşitli etkileri vardır. Nötrofil-lenfosit (N/L) oranı, kardiovasküler hastalıklar ve ateroskleroz ile ilişkili bulunmuştur. Biz çalışmamızda, aşikar ve subklinik hipotiroidili hastalarda karotis arter intimia media (KİM) kalınlığı ve N/L oranı arasındaki ilişkiyi de- ğerlendirmeyi amaçladık.Yöntemler: Çalışmamız 36 subklinik hipotiroidi (SH) ve28 aşikar hipotiroidi (AH) tanılı hasta ve 30 sağlıklı gönüllüyü içermektedir. Tüm vakaların KİM kalınlığı, tiroid hormon seviyeleri, tam kan sayımı ve lipit parametreleriölçüldü. N/L oranları için korelasyon ve lineer regresyon analizleri uygulandı.Bulgular: Kontrol grubunda, SH ve AH’li hastalarda ortalama KİM kalınlığı sırasıyla 0,51 ± 0,15, 0,58 ± 0,16, 0,67 ± 0,24 mm bulundu. AH’li hastalarda KİM kalınlığı, sağlıklı gönüllülere göre daha yüksekti (p < 0,05). Ancak, SH’lihastalarda KİM kalınlığı, diğer gruplardan farklı bulunma-dı (p > 0,05). KİM kalınlığı ile N/L oranı arasında herhangibir korelasyon saptanmadı (p < 0,05).Sonuç: Aşikar ve subklinik hipotroidisi bulunan hastalarda N/L oranları benzerdi ve aterosklerotik belirteçlerleilişkisi saptanmadı.

Carotid intima-media thickness and neutrophils/lymphocytes ratio in patients with overt and subclinical hypothyroidism

Objective: Hypothyroidism, whether overt or subclinical, has multiple effects on the cardiovascular system. Neutrophil-lymphocyte (N/L) rate is closely related to cardio- vascular disorders and atherosclerosis. Our study aimed to assess N/L rate and carotid artery intima-media thick- ness (CIMT) in patients with overt and subclinical hypo- thyroidism (SCH). Methods: The study included 36 patients with SCH and 28 patients with overt hypothyroidism (OH) as well as 30 healthy controls. CIMT, thyroid hormone levels, complete blood count and lipid parameters were measured in all subjects. Correlation analysis and linear regression analysis were performed for N/L rate. Results: Mean CIMT was 0.51 ± 0.15, 0.58 ± 0.16, 0.67± 0.24 mm in control, SCH, and OH groups, respectively.CIMT of OH patients was high compared with control sub- jects (P < 0.05). CIMT of SCH patients were not different compared with control subjects and OH patients (P > 0.05). It was no correlation that CIMT between N/L ratio (p > 0.05). Conclusion: Neutrophil-lymphocyte rate was not found to be useful indicator of early atherosclerosis in SCH and OH patients.

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