Mine Dosay AKBULUT

4751

The determination of mast cell and its secretions (Specifically histamine and nerve growth factor) roles on neuroimmune and endocrine system

Mast hücreleri bağışıklık sistemi ve yangısal reaksiyonlarla, sinir sistemi ve salgı sistemi aracılığı ile kan ile beyin arasindaki dengenin bütünlüğünü korumak üzere gösterdiği etki ve bunlara karşı sahip olduğu sorumlulukla tanımlanmaktadır. Mast hücrelerinin NGF (sinir büyütme faktörü) sentezleme ve salgılama yeteneği, maruz kalınan zararlı ve öldürücü etki yapabilen olaylar sonrası çok iyi yapılanmış olan doku savunma mekanizmasının varlığını işaret eder. Mast hücreleri NGF salgılayarak bilgileri sinir sistemine iletir ve mast hücreleri sayısını artırarak mast hücrelerinin yaşama, farklılaşma ve salgı salgılama yeteneğini olumlu yönde etkiler. Mast hücreleri'nin MS ve Alzeimer hastalığı gibi sinirsel yangı vakalarında da rolü olduğu belirlenmiştir.

Mast hüçreleri ve salgılarının (Histamin ve sinir büyütme faktörü) nöroimmün ve iç salgı sistemlerindeki rollerinin belirlenmesi

Mast cells was described as being have a responsibility and effect in the immune system and in inflammatory reactions, into the nervous system and blood, brain, barrier (BBB) integrity with endocrine system. The ability of mast cells to synthesize and release NGF has a role on maintaining the well-integrate tissue defense mechanism after noxious perturbations. Mast cell via releasing NGF transmit the information to nervous system and may lead an increase in mast cell number in vivo and effect the mast cell survival, differentiation, and mediator release in vitro. Mast cells have been implicated in the some neuroinflammatory conditions, such as multiple sclerosis (MS), and Alzheimer's disease.
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Journal of Cell and Molecular Biology-Cover
  • ISSN: 1303-3646
  • Yayın Aralığı: 2
  • Yayıncı: Haliç Üniv. Fen Edebiyat Fak.
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