Germination and seedling establishment are critical stages in the life cycle of plants especially under stress conditions. The objective of this study was to evaluate the effect of osmopriming on germination and seedling growth of Soybean (Glycine max L.) seeds under drought stress. Seeds were primed in aerated solutions of PEG 6000, KNO3 and KH2PO4 have -1.2 MPa osmotic potential. Drought levels were 0 (control), 3,-6,-9 bar. Stress condition was created by using PEG6000. Final germination percentage, time to get 50% germination (T50), seedling vigor index (SVI), germination index (GI), reduction percentage of germination (RPG), seedling dry weight and length were measured. The results indicated that inhibition of germination and seedling growth due to drought stress should be overcome b y using osmopriming treatments in soybean. A mong t he m aterials u sed f or o smopriming P EG 6 000 has t he g reatest i mpact o n m itigating t he effects of d rought s tress on germination and early growth stages