Muzaffer KEKLİK, Uğur KALAN, Özerhan ÖZER, Ferhat ARIK, Sevgi BAYRAM

Detection of vitamin B12 deficiency in patients with major depression (Major depresyon hastalarında vitamin B12 eksikliğinin tespiti)

Amaç: Vitamin B12 tüm vitaminler içindeki en karmaşık kimyasal yapıya sahip olanı olup, hematolojik ve sinirsel sistemin normal fonksiyon görebilmesi için gereklidir. Dolayısıyla, vitamin B12 eksikliği tedavi edilmediğinde depresyon gibi psikiyatrik belirtilere yol açabilir. Bu çalışmada amacımız, majör depresyon tanılı hastalarda vitamin B12 eksikliği sıklığını tespit etmekti. Metod: Çalışmada Kayseri Eğitim ve Araştırma Hastanesi’nde DSM-5 kriterleri baz alınarak majör depresyon tanısı konan 425 erişkin hastaya ait veriler değerlendirildi. Tüm hastaların CBC, serum vitamin B12 ve folat düzeyleri ile rutin biyokimyasal tetkikleri incelendi. Bulgular: Toplam 425 depresif hastanın verileri incelendi. Hastaların %74.6’sı kadındı. Vitamin B12 eksikliği 93 hastada tespit edildi (% 21.9). Kadınlarda vitamin B12 eksikliği % 22.7 iken, erkeklerde bu oran % 19.4 olarak saptandı. Her iki cinsiyet grubunda da folik asit, Hb, PLT ve WBC sayılarında anlamlı farklılık yoktu. Sonuç: : Bu çalışmanın sonuçları, majör depresyon hastalarında vitamin B12 eksikliğinin nadir olmadığını göstermiştir. Depresif semptomları olan hastalarda fizik bulguları değerlendirmek ve vitamin B12 eksikliğini saptamaya yönelik gerekli testleri yapmak faydalı olabilir. Aim: Vitamin B12 has the most complex chemical structure of all vitamins and it is necessary for normal functioning of hematological and nervous system. Thus, vitamin B12 deficiency could cause psychiatric symptoms such as depression when it is untreated. Our aim was to determine vitamin B12 deficiency frequency of patients diagnosed with major depression. Method: The present study included 425 adult patients with major depression based on Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) criteria at Kayseri Education and Research Hospital. In all patients, laboratory evaluations were performed: complete blood count (CBC), serum vitamin B12 and folate levels, and routine biochemical tests. Results: The results of 425 depressive patients were analyzed. Depression was prevelant among females (74.6%). Also, total 93 patients (21.9%) were vitamin B12 deficient. While in female patients vitamin B12 deficiency was 22.7%, in male patients, the rate was 19.4%. There were no significant differences between folate and hemoglobin (Hb) levels, platelet (PLT) and white blood cell (WBC) counts. Conclusion: The results of this study shown that, the frequency of vitamin B12 deficiency among people is major depression not uncommon. It would be beneficial to consider the physical symptoms and to conduct the required examinations to determine vitamin B12 deficiency among this patients.

Anahtar Kelimeler:

depression, depresyon, vitamin B12

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