ntrauterin HCG Enjeksiyonu IVF' te Hangi Hastalara Uygulanmalıdır?
Amaç: İn vitro fertilizasyon (IVF) tedavisinde embryo transferinden önce yapılan intrauterin human chorionic gonadothropin enjeksiyonlarının etkisinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntemler: Yüz atmış sekiz hasta çalışma grubuna alındı. 274 hasta ise kontrol grubuna dahil edildi. Hasta grupları kendi içinde de ikiye ayrıldı. Grup 1: Birinci ve ikinci IVF denemesi olan çalışma grubu hastaları (N:126) Grup 2: Birinci ve ikinci IVF denemesi olan control grubu hastaları (N:189) Grup 3: Üç veya daha fazla IVF denemesi olan çalışma grubu hastaları (N:42) Grup 4: Üç veya daha fazla IVF denemesi olan control grubu hastaları. (N:85). Tüm hastalara taze embryo transferi (ET) yapıldı. Çalışma grubuna ET öncesi intrauterine hcg enjeksiyonu uygulandı. Bulgular: Üç veya daha fazla sayıda IVF uygulaması yapılmış hastalarda gebelik , klinik gebelik ve implantasyon oranları intrauterine hCG enjekte edilenlerde belirgin düzeyde yüksek çıkmıştır. (p=0,03, p=0,02, p=0,02 sırasıyla) Sonuç: Intrauterin hCG enjeksiyonu tekrarlayan IVF başarısızlığı olan hastalarda gebelik oranlarını iyileştirmektedir.
To Which Patients Should Intrauterine HCG Injection Be Applied In In Vitro Fertilization?
Aim: To investigate the impact of the intrauterine injection of hCG before embryo transfer in in vitro fertilization (IVF) according to number oftransfer.Material And Methods: One hundred and sixty-eight (168) patients wereincluded to the study group; 274 patients were included to the controlgroup. The patients were divided into 2 study and 2 control groups.Group 1:Study group patients in the first and the second IVF cycles.(N=126)Group 2:Control group patients in the first and the second IVF cycles.(N=189)Group 3:Study group patients in the third or more IVF cycles. (N=42)Group 4:Control group patients in the third or more IVF cycles. (N=85)Fresh IVF-embryo transfer (ET) was performed to all patients. IntrauterinehCG injection was performed before ET in the study groups.Results: The pregnancy, clinical pregnancy and implantation rates weresignificantly increased in the intrauterine hCG injected patients with thirdor more IVF cycles (p= 0.03, p= 0.02, p= 0.02) respectively.Conclusion: The intrauterine hCG injection improved the pregnancy ratesin the patient with recurrent IVF failures.
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