Gestasyonel Diabetli Hastalarda Serum Homosistein Düzeyleri Değişimi

Amaç: Bu çalışmanın amacı gestasyonel diabet tanısı almış olan hastalarda maternal homosistein düzeylerinin araştırılması, diabetik olmayan hastalarla karşılaştırılması ve hastalıkla olası ilgisinin değerlendirilmesidir.Gereç ve Yöntemler: Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi Yüksek Riskli Gebelikler servisinde takipleri ve doğumu gerçekleştirilen hastalardan, gestasyonel diabet tanısı almış olanlar çalışma grubunu, diabet tanısı olmayan hastalar kontrol grubunu oluşturacak şekilde prospektif olarak toplandı. Hastaların demografik verileri doğum yaptıkları gebelik haftası, doğum şekli, yenidoğanların ağırlığı, neonatal takipte ortaya çıkan özellikler kaydedildi. Tüm gebeler 24-28. gestasyonel haftalar arasında rutin olarak gestasyonel diabet taramasından geçirildi. Homosistein düzeyleri ve metionin-homosistein metabolizmasında çok önemli yer tutmaları nedeniyle hastaların folik asit ve vitB12 düzeyleri ve ayrıca albümin düzeyleri de değerlendirildi.Bulgular: GDM’ si olan ve olmayan hastaların karşılaştırmasında GDM olan hastalarda gravida ve pariteler, hastaların yaşları, ve gebelerin kilo alımı anlamlı olarak daha fazla bulundu p

Anahtar Kelimeler:

Gestasyonel diabet, homosistein, folik asit

Changes Of Serum Homocysteine Levels In Patients With Gestational Diabetes Mellitus

Aim: To investigate homocysteine levels in patients with gestational diabetes, compare with non-diabetic patients and search the potential relation with disease.Material And Methods: Patients whose medical examinations and births were performed in Zekai Tahir Burak Women Health and Research Hospital High Risk Pregnancy Clinic were included to study prospectively.Gestational diabetic patients were enrolled as study group and non-diabetic patients were enrolled as control group.Demographic data of the patients, gestational age at birth, birth type, birthweight of newborns and complications occured during neonatal follow-up were recorded.All patients were scanned for gestational diabetes between 24-28 weeks.Homocysteine levels and -because they are very important for methionine-homocysteine metabolism- folic acid and vit B12 levels were evaluated.Results: When patients with and without GDM were compared, ages of the patients;gravidy-parity and weight gains during pregnancy were significantly higher for patients with GDM p

Keywords:

Gestational diabetes, homocysteine, folic acid,

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