Betül TAŞ, Sibel ALPER, Banu TAŞKIN, Zahide ERIŞ EKEN

PEDİATRİK VİTİLİGO HASTALARINDA 308-NM EXCİMER LAMBA VE TOPİKAL TAKROLİMUS KOMBİNASYONUNUN ETKİNLİĞİ

Giriş:Çalışmanın amacı pediyatrik vitiligo hastalarında monokromatik 308-nm Excimer lamba ve topical takrolimus kombinasyonunun klinik etkinliğini ve güvenliğini araştırmaktır. Gereç ve Yöntem:Çalışmaya 20 pediatrik hastaya ait 37 vitiligo patch dahil edildi. Lezyonlara günde iki kez takrolimus % 0.03 krem ile haftada iki kez, toplam 20 seans 308 nm excimer ışık tedavisi uygulandı. Hastaların demografik verileri, özgeçmişleri, tedavi yanıtları retrospektif olarak değerlendirildi. Tedavi alanları; baş ve boyun, gövde ve üst ve alt ekstremite olarak gruplandı. Tedavi yanıtları klinik olarak 0 ve 4 arasında; 0, pigmentasyon yok; % 1, 1 ila % 25 pigmentasyon; % 2, 26 ila% 50 pigmentasyon; 3, 51 ila 75% pigmentasyon; ve 4,>% 75 pigmentasyon şeklinde derecelendirildi. Bulgular:37 vitiligo yamasının topical tedavive 20 seans mikrofototerapi sonrasında sırasıyla% 24’ünde ≥% 75,% 14’ünde % 51-75,% 16’sında % 26-50 ve% 27'sinde % 1-25 oranında repigmentasyon gözlendi. Vakaların % 19'unda 24 saatten kısa süren geçici eritem görüldü. Sonuç:Takrolimus krem ve 308-nm excimer ışık tedavisi kombinasyonu, pediyatrik vitiligo hastalarının tedavisi için güvenli ve etkili bir alternatiftir

THE EFFICACY OF 308-NM EXCIMER LAMP IN COMBINATION WITH TOPICAL TACROLIMUS CREAM IN PEDIATRIC VITILIGO

Introduction: To investigate the clinical efficacy and safety of acombination of monochromatic 308-nm excimer lamp therapy and topical tacrolimus for the treatment of pediatric vitiligo. Materials and Method: A total of 37 vitiligo patches from 20 pediatric patients were included in the study. Treatment consisted of 308-nm excimer light therapy administered twice weekly for a total of 20 sessions with twice daily application of 0.03% tacrolimus cream. Demographic data, past medical history, treated areas, and responses were recorded and evaluated, retrospectively. The treatment areas were grouped as follows: head and neck, trunk, and upper and lower extremities. Treatment responses were clinically rated between 0 and 4 as follows: 0, no pigmentation; 1, 1 to 25% pigmentation; 2, 26 to 50% pigmentation; 3, 51 to 75% pigmentation; and 4, >75% pigmentation. Results:After 20 treatments, ≥ 75%, 51-75%, 26-50%, and 1-25% pigmentation was observed in 24%, 14%, 16%, and 27% of the 37 vitiligo patches, respectively. Tr ansient erythema lasting for less than 24 hours was observed in 19% of the cases. Conclusion: The tacrolimus and 308-nm excimer light therapy combination represent a safe and effective alternative for the treatment of patients with pediatric vitiligo.

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