Hüseyin OFLAZ, Burak PAMUKÇU, İmran ONUR, Nilgün ERTEN, Sami UZUN, Mehmet Akif KARAN, Cemil TAŞÇIOĞLU, Abdülkadir KAYSI, Bülent SAKA, Bahat Gülistan ÖZTÜRK, Sema GENÇ

İleri yaşta ortaya çıkan vasküler endotelyal disfonksiyona serum homosistein, lipoprotein(A) ve dihidroepiandrostenedion sülfat düzeylerindeki değişikliklerin katkısıi

Amaç: Vasküler endotelyal disfonksiyon (VED) ateroskleroz gelişiminde önemli bir etkendir. VED ile yaşlanma arasında ilişki olduğuna dair veriler mevcuttur. Bu çalışmadaki amacımız, yaşlıda ortaya çıkan VED'e serum homosistein, lipoprotein (a) ve dihidroepiandrostenedion sülfat (DHEAS) düzeylerindeki değişikliklerin katkısının olup olmadığının araştırılmasıdır. Gereç ve yöntem: Tümü hipertansif olan 67 ileri yaşlı ve 35 orta yaşlı hasta çalışmaya dahil edildi. Diyabet ve diğer kardiyovasküler risk faktörleri olan hastalar çalışmaya alınmadı. Hastaların brakiyal arterlerinde oluşturulan geçici iskemi sonrası ortaya çıkan vazodilatasyon (flow mediated dilation, FMD) düzeyi ve karotis arterlerinin intima media kalınlıkları (KAIMK), yaş, vücut kitle indeksi, sistolik ve diyastolik kan basıncı, serum lipid, glukoz, kreatinin, lipoprotein (a), homosistein ve DHEAS düzeyi ile karşılaştırıldı.Bulgular: FMD'nin yaş ve KAIMK ile ters orantılı olduğu bulundu (p

Impact of serum homocystein, lipoprotein (A), and dihydroepiandrostenedion sulphate levels on vascular endothelial dysfunction in the elderly

Objective: Vascular endothelial dysfunction (VED) is an important factor in the development of atherosclerosis. There are evidences about association of aging with VED. In this study, our aim is to identify if serum levels of homocystein, lipoprotein (a), apolipoproteins and dihydroepiandrostenedion sulphate interfere with vascular endothelial function in elderly. Materials and Methods: Sixty-seven hypertensive elderly patients and 35 hypertensive middle-aged patients were included into the study. Patients with diabetes and other cardiovascular risk factors were excluded. We compared flow mediated vasodilation of the brachial artery (BA) (FMD%) and carotid artery intima media thickness (CAIMT) of the patients with their ages, body mass indexes, systolic and diastolic blood pressures, serum lipids, glucose, creatinine, lipoprotein (a), homocystein and dihydroepiandrostenedion sulphate (DHEAS) levels.Results: FMD% was found inversely correlated with age and CAIMT (p

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