SPECTROPHOTOMETRIC DETERMINATION OF AMANTADINE HYDROCHLORIDE IN CAPSULES

Amantadine HCl antiviral ve antiparkinson etkili bir ilagtlr. Bu Gahgmada amantadine HCl in 1,2-naftokinon-4-sulfonik asit sodyum tuzu ile olugturduii;~ tiirev yardlrm ile spektrofotometrik milstar tayini geligtirilmigtir. Reaksiyon sulu ortamda, pH 10 da, 60 "C da ve 30 dakilsada tamamlanmaktaclr. Olugan tiirevin maksimum absorpsiyonu 451 nrn'de gozlenmigtir. 0lqu egrisi 5-25 pglrnl araslnda do$jrusaldlr. Geligtirilen yontem amantadin HC1 ic;eren kapsullere uygulm~ ve sonuglar USP XXIII yonterni ile istatistik olarak hyaslmgtlr.

Anahtar Kelimeler:

Amantadine HC1, spectrophotometric determination, 1, 2- naphtoquinone-4-sulphonic acid

SPECTROPHOTOMETRIC DETERMINATION OF AMANTADINE HYDROCHLORIDE IN CAPSULES

Amantadine HCl is used as an antiviral and an antiparkinson drug. We described spectrophotometric determination of amantadine HCl by derivatization with sodium 1,2-naphtoquinone-4-sulfonate in aqueous medium. The structure of the derivative was determined by IR, HI-NMR and mass spectral methods. The derivative was obtained quantitatively at pH 10 and 60 "C in 30 minutes and showed maximum absorption at 451 nm. The calibration curve obeys Beers's Law in the 5-25 pg/ml range. The proposed method was applied to the determination of amantadine HCl in pharmaceutical dosage form (capsule). The results were statistically compared with USP XXIII procedure.

Keywords:

Amantadine HC1, spectrophotometric determination, 1, 2- naphtoquinone-4-sulphonic acid,

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