The White Spot Syndrome Virus (WSSV) has been the most pathogenic virus in the shrimp and other crustacean industries across the world in terms of production and financial benefits. Invertebrate vectors, freshwater, and sediments spread it horizontally as well as vertically from diseased brood stocks to post larvae. It is an exceedingly contagious disease that may cause entire mortality within 3–10 days of an outbreak under standard culture conditions. The sequencing and characterization of several WSSV strains has begun to reveal information regarding pathogen biology, pathogenicity, and WSSV must bind to the shrimp digestive system in order to infect it, and failure to do so results in ineffective infection. The peneaus monodon chitin binding protein (PmCBP) as well as the viral envelope proteins VP24 and VP28 are required for viruses to bind to shrimp digestive system. In this study, we have shown the molecular interactions between PmCBP-VP24 and PmCBP-VP28 complex and speculated about first steps of virus ingression in shrimps for the first time.