Determination and Speciation of Selenium in Pharmaceutical Samples, Spiked Veterinary Drug Samples with a Kinetic Catalytic Method
Determination and Speciation of Selenium in Pharmaceutical Samples, Spiked Veterinary Drug Samples with a Kinetic Catalytic Method
In the present study a new kinetic catalytic method was developed for the sensitive determination of selenium in pharmaceutical formulations. The reaction between basic blue 3 (BB3) and sulphide catalysed by Se (IV) in the presence of acetic-phosphoric-boric acid buffer system. The decrease in the absorbance at 654 nm indicated the reduction of BB3. The presence of selenium (IV) accelerated the reaction rate. The method based on the linear correlation between amount of Se(IV) and reaction rate. Under optimum conditions, the linear calibration range was found as 0.1-2.0 µg ml-1 by the fixed time method for the 0.5-5 min. The tolerance limits of various species was also studied. The interfering effect of some cations such as Cr3+, Fe3+, and Hg2+ was reduced with using cation exchange resin. The proposed method was successfully applied to spiked nasal spray and veterinary drug samples. Besides, total selenium, Se (IV) and Se (VI) speciation also conducted with reducing Se (VI) to Se (IV) with HCl in the synthetic mixtures.
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- 1. Miletić D, Turło J, Podsadni P, Pantić M, Nedović V, Lević S, &
Nikšić M. Selenium‐enriched Coriolus versicolor mushroom
biomass: potential novel food supplement with improved selenium
bioavailability. J Sci Food Agric. 2019; 99(11):5122-5130.
- 2. Tolu J, Bouchet S, Helfenstein J, Hausheer O, ChékifiS, Frossard
E, Tamburini F, Chadwick OA, Winkel LH. Understanding soil
selenium accumulation and bioavailability through size resolved
and elemental characterization of soil extracts. Nat Commun. 2022;
13(1):1-16.
- 3. Amin N, Afkhami A, Madrakian T. Construction of a novel" Off-
On" fluorescence sensor for highly selective sensing of selenite
based on europium ions induced crosslinking of nitrogen-doped
carbon dots. J Lumin. 2018; 194:768-777.
- 4. Brusa L, Tudino M, Schlotthauer J, Sigrist M. Selenium speciation
in soils using flow injection hydride generation atomic absorption
spectrometry with on-line removal of organic matter interferences.
Talanta. 2023; 253:123898.
- 5. Gómez-Nieto B, Gismera MJ, Sevilla MT, Procopio JR. Direct
solid sampling of biological species for the rapid determination
of selenium by high-resolution continuum source graphite
furnace atomic absorption spectrometry. Anal Chim Acta. 2022;
1202:339637.
- 6. Lashari AA, Kazi TG, Baig JA, Afridi HI, Memon AA. Speciation of
the Selenium in Groundwater Samples of Different Aquifers from
Coal Mining Fields: Applied a Green Analytical Technique. Water
Air Soil Pollut. 2022; 233(11):1-11.
- 7. Souza SO, Ávila DVL, Cerdà V, Araujo RGO. Selenium inorganic
speciation in beers using MSFIA-HG-AFS system after multivariate
optimization. Food Chem. 2022; 367:130673.
- 8. Merino IE, Stegmann E, Aliaga ME, Gomez M, Arancibia V, Rojas
C. Determination of Se (IV) concentration via cathodic stripping
voltammetry in the presence of Cu (II) ions and ammonium diethyl
dithiophosphate. Anal Chim Acta. 2019; 1048:22-30.
- 9. Stoica A, Babaua GR, Iorgulescu EE, Marinescu D, Baiulescu GE.
Differential pulse cathodic stripping voltammetric determination
of selenium in pharmaceutical products. J Pharm Biomed Anal.
2002; 30(4):1425-1429.
- 10. Martins FCOL, De Souza D. Ultrasensitive determination of
selenium in foodstuffs and beverages using an electroanalytical
approach. Microchem J. 2021; 164:105996.
- 11. Wei H, Pan D, Cui Y, Liu H, Gao G, Xia J. Anodic stripping
determination of selenium in seawater using an electrode modified
with gold nanodendrites/perforated reduced graphene oxide. Int J
Electrochem Sci. 2020; 15:1669-1680.
- 12. Kim IJ, Watson RP, Lindstrom RM. Accurate and precise
measurement of selenium by instrumental neutron activation
analysis. Anal Chem. 2011; 83(9):3493-3498.
- 13. Srivastava A, Bains GS, Acharya R, Reddy AVR. Study of
seleniferous soils using instrumental neutron activation analysis.
Appl Radiat Isot. 2011; 69(5):818-821.
- 14. El-Ghawi UM, Al-Fakhri SM, Al-Sadeq AA, Bejey MM, Doubali
KK. The level of selenium and some other trace elements in
different Libyan arable soils using instrumental neutron activation
analysis. Biol Trace Elem Res. 2007; 119(1):89-96.
- 15. Messaoudi M, Begaa S. Radiochemical neutron activation analysis
for the determination of selenium in Mentha spicata L. samples
collected from Djelfa, Algeria region. Radiochim Acta. 2020;
108(3):217-222.
- 16. Pyrzynska K, Sentkowska A. Liquid chromatographic analysis of
selenium species in plant materials. Trends Analyt Chem. 2019;
111:128-138.
- 17. Li YF, Chen C, Li B, Wang Q, Wang J, Gao Y, Zhao Y, Chai Z.
Simultaneous speciation of selenium and mercury in human
urine samples from long-term mercury-exposed populations with
supplementation of selenium-enriched yeast by HPLC-ICP-MS. J
Anal At Spectrom. 2007; 22(8):925-930.
- 18. Ballihaut G, Kilpatrick LE, Kilpatrick EL, Davis WC. Detection and
characterization of selenoproteins by tandem mass spectrometry
assisted by laser ablation inductively coupled plasma mass
spectrometry: application to human plasma selenoproteins. J Anal
At Spectrom. 2011; 26(2):383-394.
- 19. Jin F, Marcus RK. Selenium compound analysis by particle beam/
hollow cathode optical emission spectroscopy (PB/HC-OES):
monitoring of carbon and hydrogen emission from organoselenium
compounds. J Anal At Spectrom. 2003; 18(6):589-595.
- 20. Fang Z, Xu S, Tao G. Developments and trends in flow injection
atomic absorption spectrometry. J Anal At Spectrom. 1996; 11(1):1-
24.
- 21. Chen D, Luque de Castro MD, Valcárcel M. Determination of
anions by flow injection. A review. Analyst. 1991; 116(11):1095-1111.
- 22. Milovanović GA, Petronijević RB, Čakar MM. Kinetic
determination of trace levels of selenium (IV) and total selenium
by Nile Blue A/hydrogen peroxide method. Microchim Acta. 1998;
128(1):43-48.
- 23. Keyvanfard M, Sharifian A. Kinetic spectrophotometric method
for the determination of selenium (IV) by its catalytic effect on the
reduction of spadns by sulphide in micellar media. J Anal Chem.
2006; 61(6):596-600.
- 24. Zaporozhets OA, Bilikon SL. A visual test method for determining
selenium(IV) with indigocarmine immobilized on silica. J Anal
Chem. 2007; 62(2):188-192.
- 25. Absalan G, Safavi A, Maesum S. Application of artificial neural
networks as a technique for interference removal: kinetic–
spectrophotometric determination of trace amounts of Se (IV) in
the presence of Te (IV). Talanta. 2001; 55(6):1227-1233.
- 26. Gainutdinova DF, Shirshova NV, Toropova VF, Budnikov GK,
Garifzyanov AR. Reaction of 2, 3-dimethylmercaptopropionic
acid with methylene Blue as an indicator reaction for the kinetic
determination of selenium. J Anal Chem. 2001; 56(6):564-566.
- 27. Gudzenko LV, Pantaler RP, Blank AB. Catalytic spectrophotometric
determination of nanogram amounts of selenium (IV). J Anal
Chem. 2004; 59(10):935-938.
- 28. Huizhi LI, Diantang Z, Yingju F. Catalytic spectrophotometric
determination of trace selenium in microemulsion after separation
and enrichment by SDG. Rare Metals. 2006; 25(3):281-286.
- 29. Safavi A, Sedghy HR, Shams E. Kinetic spectrophotometric
determination of trace amounts of selenium and vanadium.
Fresenius J Anal Chem. 1999; 365(6):504-510.
- 30. Zhengjun G, Xinshen Z, Guohe C, Xinfeng X. Flow injection
kinetic spectrophotometric determination of trace amounts of Se
(IV) in seawater. Talanta. 2005; 66(4):1012-1017.
- 31. Rohn I, Marschall TA, Kroepfl N, Jensen KB, Aschner M, Tuck
S, Kuehnelt D, Schwerdtle T, Bornhorst J. Selenium speciesdependent toxicity, bioavailability and metabolic transformations
in Caenorhabditis elegans. Metallomics. 2018; 10(6):818-827.
- 32. Khajehsharifi H, Mousavi MF, Ghasemi J, Shamsipur M. Kinetic
spectrophotometric method for simultaneous determination of
selenium and tellurium using partial least squares calibration. Anal
Chim Acta. 2004; 512(2):369-373.
- 33. Gürkan R, Akcay M. Kinetic spectrophotometric determination
of trace amounts of selenium based on the catalytic reduction maxilon blue-SG by sulfide. Microchem J. 2003; 75(1):39-49.