Metin ÇENESİZ, Elif BAYRAM, Semra OKUR GÜMÜŞOVA

Viral Enfeksiyonlarda Telomeraz Aktivitesi

Lineer kromozomların uçlarında yer alan telomer adı verilen yapılar kromozomların bütünlüğünü sağlar. Kısa telomerler, DNA hasarında oluşan sinyale benzer bir sinyal üreterek, gerek yaşlanmayı gerekse de programlı hücre ölümünü tetikler. Telomeraz enzimi de kısalan telomerleri onararak telomer zincirlerinin uzun kalmasını sağlar. Böylece hücrelerin bölünme kapasitesinde artış sağlanmış olur. İnsan ve hayvan onkojenik viruslarının, geliştirdikleri mekanizmalarla telomeraz enzimini yeniden aktive edebildikleri ispatlanmıştır. Bu derleme viral enfeksiyonlar ile telomeraz aktivitesi arasındaki ilişkinin incelendiği bir dizi çalışmadan hazırlanmıştır.

Anahtar Kelimeler:

Viral enfeksiyonlar, Telomer, Telomeraz

Telomerase Activity in Viral Infections

The structures at the ends of linear chromosomes called telomeres provide the integrity of the chromosomes. Short telomeres produce a signal similar to DNA damage and triggering both programmed cell aging and programmed cell death. Also, telomerase enzyme restores shortened telomeres and allowing telomerase chains to stay longer. Thus increases the cleavage capacity of the cells. It has been proven that human and animal oncogenic viruses can re-activate telomerase enzyme in the cell through their new developed mechanisms. This review is prepared with series of studies that is examined the relationship between viral infections and telomerase activity.

Keywords:

Viral infections, Telomer, Telomerase,

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