Tip II Diyabetes Mellituslu Hastalarda Serum Ürik Asit Ve Gama Glutamil Transferaz Düzeyleri İle Koroner Arter Hastalığı Gelişimi Arasındaki İlişki
Amaç: Çalışmamızda koroner arter hastalığının (KAH) eşlik ettiği tip 2 diyabetesmellituslu (DM) hastalarla
tip 2 DM tanısıyla takip edilen hastalar serum ürik asit (SÜA) ve gama glutamiltransferaz (GGT) düzeyleri
diğer metabolik parametreler ile birlikte incelenerek prospektif olarak karşılaştırılmış; diyabetik hastalarda
bu parametreler ile KAH gelişimi arasındaki ilişki ortaya koymak amaçlanmıştır.
Gereç ve Yöntem: Kahramanmaraş Necip Fazıl Şehir Hastanesi\'nde gerçekleştirilen bu çalışmaya,
kardiyoloji polikliniğine başvuran tip II DM'lI 118 hasta, KAH\'nın eşlik ettiği 222 adet tip 2 DM\'li hasta
dahil edildi.
Bulgular: Guruplar arasında SÜA düzeylerinde anlamlı farkın olmadığı (5.37±1.48 vs 5.27±1.51 mg/dl;
p=0.194), GGT düzeyinin ise tip II DM'nin eşlik ettiği KAH olan grupta sadece tip II DM olan gruba göre
istatistiki olarak anlamlı olarak daha yüksek olduğunu tespit ettik(23,0 (16,0-32,50) vs 25 (18,0-39,0) U/L; P
< 0,0001).
Sonuç: Çalışmamızda serum GGTdüzeyinin diyabetli hastalarda kardiyovasküler riskin artışını gösteren bir
prediktör olabileceğini gözlemledik. Ancak SÜAseviyesiyle tip II DM'li hastalarda KAH riski arasında ilişki
saptanamamıştır
The Relationship Between Type 2 DM Patients With Serum Uric Acid And Gamma Glutamyl Transferase Levels and Development Coronary Artery Disease
Objective: In this study we prospectively compared the patients with coronary artery disease (CAD)
accompanied type 2 diabetes mellitus (DM) and patients followed with type 2 diabetes in view of the serum
uric acid (SUA) and glutamil gamma transferase (GGT) levels furthermore metabolic parameters; it is
targeted to reveal the relationship between these parameters and CAD development risk in diabetic patients.
Materials-Methods: 118 patients with type ll DM and 222 type 2 DM patients with CAD who were applied
to the cardiology output clinic enrolled to the study.
Results: No significant difference was established between groups for SUAlevels (5.37 ± 1,48 vs 5.27±1,51
mg/dl; p=0,194) , while the GGT levels in CAD with type ll DM detected statistically significent higher than type II DM group(23.0 (16,0-32,50) vs 25 (18,0-39,0)U/L; P< 0,001).
Conclusion: We observed serum GGTlevels in DM patients are a predictor of the raising cardiovascular risk.
However, SUAlevels in type II DM are not have a relation with the risk of CAD.
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