Ahmet ÇELİK, Hatice SEZEN, Yusuf SEZEN, Elif ŞAHİN, Sefa ÇİFTÇİ, Metin KILINÇ

Romatizmal mitral darlığında fetuin-A düzeyleri ve ekokardiyografi bulguları ile ilişkisi Türkçe

Amaç: Fetuin-A, dolaşımda bulunan, distrofik vasküler ve valvüler kalsifikasyon oluşumunu önleyen bir akut faz proteinidir. Bu çalışmanın amacı, Romatizmal Mitral Darlığı olan hastalarda serum fetuin-A düzeylerinin sağlıklı kişilere göre ne yönde değiştiğini ve ekokardiyografi bulguları ile ilişkili olup olmadığını belirlemektir.Materyal ve metod: Tanısı Ekokardiyografi ile konmuş, Romatizmal Mitral Darlığı olan elli hasta ve yaş ve cinsiyet karşılaştırmalı elli iki sağlıklı kişi çalışmaya dahil edildi. Her bireyin serum Fetuin-A düzeyi ELISA metodu ile ölçüldü.Bulgular: Hastalar ile kontrol grubu arasında serum Fetuin-A düzeyleri yönünden anlamlı fark yoktu sırasıyla 29,35±6,41 ng/mL ve 27,64±6,35 ng/mL; p=0,262 . Hastalarda Ekokardiyografi ile belirlenen Wilkins kalsifikasyon skoru ile serum Fetuin-A düzeyleri arasında anlamlı korelasyon bulunmadı.Sonuç: Hastaların kullanmakta oldukları antimikrobiyal ve antiinflamatuar ilaçların etkisiyle serum FetuinA düzeylerinin düşmesi önlenmiş olabilir. İki boyutlu Ekokardiyografi ile değerlendirildiğinde Mitral kapaktaki kalsifikasyonun derecesi ile serum fetuin-A düzeyi arasında anlamlı bir ilişki bulunmamıştır

Anahtar Kelimeler:

Fetuin-A, romatizmal kalp kastalığı, ekokardiyografi

Fetuin-A levels in rheumatismal mitral stenosis and its relationship with echocardiographic findings

Background: Fetuin-A is an acute phase protein that exists in circulation and prevents the formation of dystrophic vascular and valvular calcification. The aim of this study was to determine how serum fetuin-A levels changed in Rheumatic Mitral Stenosis patients when compared to healthy control subjects and whether it was associated with echocardiographical data.Methods: Fifty Rheumatic Mitral Stenosis patients diagnosed by echocardiography and age-sex matched fifty-two control subjects were included into the study. Serum fetuin-A level of each subject was measured by ELISA method.Results: There was no significant difference between patients and controls in serum fetuin-A levels respectively 27,64±6,35 ng/mL and 29,35±6,41 ng/mL; p=0,262 . In additon, no significant correlation was found between Wilkins calcification score determined by echocardiography and serum fetuin-A levels in patients.Conclusions: Decrease of serum fetuin-A levels might have been inhibited due to the usage of antimicrobial and antiinflammatory drugs of patients. A significant relationship wasn't found when serum fetuin-A levels and calcification in the mitral valve determined by ecocardiographic data were correlated in these patients

Keywords:

Fetuin-A, rheumatismal heart disease, echocardiography,

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