Handan AKAR, Nilgün CENGİZ, Abdülkerim BEDİR, Musa Kazım ONAR

Laküner infarkt ve anjiotensin dönüştürücü enzim gen polimorfizmi arasındaki ilişki English

Amaç: Serebral laküner infarktlar ile anjiyotensin dönüştürücü enzim ADE gen polimorfizmi arası ilişkiyi araştırmak.Materyal ve metot: Çalışmaya bilgisayarlı tomografisinde laküner infarkt tespit edilen 23 hasta ile bilgisayarlı tomografisi normal olan 26 kontrol dahil edildi. Risk faktörleri olarak yaş, cinsiyet, hipertansiyon, diyabet, kalp hastalığı, hiperlipidemi ve sigara içimi alındı. Polimerize zincir reaksiyonu kullanılarak ADE geninde insersiyon delesyonlar araştırıldı.Bulgular: Laküner infarkt grubunda ortalama hiperlipidemi insidansı ve ortalama yaş kontrol grubundan daha yüksek bulundu p

Anahtar Kelimeler:

Laküner infarkt, ADE polimorfizm, genetik

The relationship between angiotensin converting enzyme gene polimorphism and lacunar infarction

Background: To evaluate the relationship between polymorphisms of the angiotensin converting enzyme ACE gene and cerebral lacunar infarction.Methods: We included 23 patients with cerebral lacunar infarct confirmed with computerized tomography CT , and 26 controls with normal CT scans. We considered age, sex, hypertension, diabetes mellitus, cardiac disease, hyperlipidemia and smoking as risk factors. Insertions or deletions I/D in the ACE gene were detected using polymerase chain reaction PCR .Results: The average incidence of hyperlipidemia and mean age were higher in the lacunar infarct group p

Keywords:

Lacunar infarction, ACE gene polymorphism, genetic,

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