Timuçin AYDOĞAN, Fatih KARABABA, Serkan YALÇIN, Salih SELEK, Turgay ULAŞ, İbrahim ARSLAN, Ahmet UYANIKOĞLU, Haşim NAR

Bir Prospektif Çalışma: İrritabl Barsak Sendromu\'nda Sitalopram Kullanımı

Amaç: İrritabl Barsak Sendromu İBS yaygın görülen bir durumdur. Medikal tedavisinde antidepresanlar ve antispazmotikler kullanılır. Çalışmamızda, selektif serotonin reuptake inhibitörü SSRI grubundan bir antidepresan olan sitalopramın, İBS semptomları ve depresyon- anksiyete skorları üzerine etkisini araştırmayı amaçladık.Materyal ve Metot: Çalışmaya, Roma 3 tanı kriterlerine göre İBS tanısı konan 103 hasta alındı. İBS'li hastalar, 3 gruba bölündü: 1. grupta n=29 Beck Depresyon Skoru BDS ve Beck Anksiyete Skoru BAS minimal- hafif derecede olan hastalara, bir antispazmotik olan otilonyum bromide 120 mg/gün verildi. 2. grupta n=41 BDS ve BAS orta- ciddi olanlara, otilonyum bromid 120 mg/gün ve sitalopram 20 mg/gün verildi. 3. grupta n=33 ise yine BDS ve BAS orta- ciddi olanlara, sadece otilonyum bromid 120 mg/gün verildi. 3 aylık tedavinin sonunda, tedavi cevapları İBS şiddeti skorlama sistemi ve BDS- BAS ile değerlendirildi. Bulgular: Tedavi sonunda 1. ve 2. gruplarda BDS ve BAS'larda anlamlı düzelmeler olurken p0,05 . İBS şiddet skorlarında ise, 1. grupta daha belirgin olmak üzere, her üç grupta da istatistiksel olarak anlamlı azalmalar oldu p0,05 .Sonuç: Bulgularımıza göre, İBS'li hastalardaki depresyon ve anksiyete şiddetli değilse, bu hastaların tedavisinde tek başına antipazmotik verilmesi, uygun bir seçenek olabilir

Anahtar Kelimeler:

İrritabl Barsak Sendromu, sitalopram, anksiyete, depresyon

The use of citalopram in Irritable Bowel Syndrome: A prospective study

Background: Irritable Bowel Syndrome IBS is a commonly seen condition. Medications used in its treatment include anti-depressants and anti-spasmotics. This study aimed to examine the effect of citalopram, a selective serotonin reuptake inhibitor groupped antidepressant on IBS symptoms and depression-anxiety scores.Materaial and Methods: 103 patients diagnosed with IBS according to the Rome 3 diagnostic criteria were included in the study. Patientswith IBS were divided into three groups:those with minimal-mild Beck Depression Score BDS and Beck Anxiety Score BAS were only given otilonium bromide 120 mg/day group 1, n=29 , those with moderate- severe scores were given otilonium bromide120 mg/day and citalopram20 mg/day group 2, n=41 and those with moderate- severe scores were only given otilonium bromide 120 mg/day group 3, n=33 . At the end of 3 months treatment, the responses to treatment were evaluated with the IBS severity scoring system and BDS-BAS.Results: While a significant improvement was detected in the BDS and BAS of first and second groups . p0,05 .Statistically significant improvementwas found in IBS severity score of three groups p0,05 .Conclusion: According to our findings, if depression and anxiety in IBS patients are not so severe, a treatment regime with only anti-spasmotics may be an appropriate choice

Keywords:

Irritable Bowel Syndrome, citalopram, anxiety, depression,

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