Evaluation of Antimicrobial Activity of Three Endemic Salvia Species Growing in Turkey
Evaluation of Antimicrobial Activity of Three Endemic Salvia Species Growing in Turkey
The ethanol extracts obtained from the aerial parts of three Salvia species (S. hypargeia,S. huberi and S. dichroantha) which are endemic to Turkey were tested for their antibacterialand antifungal activities against two Gram (+) bacterial strains [Staphylococcusaureus (ATCC 25925), Bacillus subtilis (ATCC 6633)]; three Gram (-) bacterial strains[Escherichia coli (ATCC 25923), Acinetobacter baumannii (ATCC 02026), Aeromonashydrophila (ATCC 95080)] and Mycobacterium tuberculosis H37Rv, and three fungalstrains (Candida glabrata ATCC 90030, C. parapsilosis ATCC 22019, C. tropicalisATCC 750) by using the broth microdilution method. All tested plant extracts showedsignificantly antibacterial activity against A. baumannii (ATCC 02026) (62.5 μg/mLMIC value) when compared to reference drug Ampicillin (125 μg/mL MIC value).The ethanolic extract of S. huberi was found the most effectiveness extract against M.tuberculosis H37Rv with 0.97 μg/mL MIC value when compared to reference antimycobacterialagents Isoniazid and Ethambutol (0.97 μg/mL and 1.95 μg/mL MIC values,respectively).
___
- 1. Altun M, Unal M, Kocagoz T, Goren AC: Essential oil compositions
and antimicrobial activity of Salvia Species. Journal of Essential Oil
Bearing Plants 2007, 10(3):251-258.
- 2. Kamatou GPP, Makunga NP, Ramogola WPN, Viljoen AM: South
African Salvia species: A review of biological activities and phytochemistry.
Journal of Ethnopharmacology 2008, 119:664–672.
- 3. Atas AD, Goze I, Alim A, Cetinus SA, Vural N, Goze HM, Korkoca
H: Chemical composition, antioxidant, antimicrobial activities of the
essential oil of Salvia hypargeia Fisch. & Mey. Journal of Essential
Oil Bearing Plants 2011, 14(3):289-296.
- 4. Habibi Z, Cheraghi Z, Ghasemi S, Yousefi M: A new highly hydroxylated
triterpene from Salvia atropatana Bunge. Natural Product
Research 2012, 26(20):1910-1913.
- 5. Tohma H, Koksal E, Kılıc O, Alan Y, Yılmaz MA, Gulcin I, Bursal E,
Alwasel SH: RP-HPLC/MS/MS analysis of the phenolic compounds,
antioxidant and antimicrobial activities of Salvia L. species. Antioxidants
2016, 5:38-53.
- 6. Tan N, Yazıcı-Tutunis S, Yesil Y, Demirci B, Tan E: Antibacterial
activities and composition of the essential oils of Salvia sericeo-tomentosa
varieties. Records of Natural Products 2017, 11(5):456-461.
- 7. Polat R, Cakilcioglu U, Selvi S, Turkmen Z, Kandemir A: The
anatomical and micromorphological properties of three endemic and
medicinal Salvia species (Lamiaceae) in Erzincan (Turkey). Plant
Biosystems-An International Journal Dealing with all. Aspects of
Plant Biology 2017, 151(1):63-73.
- 8. Kocak A, Bagci E: Chemical composition of essential oil of local
endemic Salvia kronenburgii Rech. fil. to Turkey. Journal of Essential
Oil Bearing Plants 2011, 14(3):360-365.
- 9. Er M, Tugay O, Ozcan MM, Ulukus D, AL-Juhaimi F: Biochemical
properties of some Salvia L. species. Environmental Monitoring
and Assessment 2013, 185:5193-5198.
- 10. Tepe B, Sokmen M, Akpulat HA, Sokmen A: Screening of the antioxidant
potentials of six Salvia species from Turkey. Food Chemistry
2006, 95:200-204.
- 11. Demirci B, Baser KHC, Yıldız B, Bahcecioglu Z: Composition of the
essential oils of six endemic Salvia spp. from Turkey. Flavour and
Fragrance Journal 2003, 18:116-121.
- 12. Topcu G, Turkmen Z, Schilling JK, Kingston DGI, Pezzuto JM,
Ulubelen A: Cytotoxic activity of some Anatolian Salvia extracts and
isolated abietane diterpenoids. Pharmaceutical Biology 2008, 46(3):
180-184.
- 13. Nielsen TRH, Kuete V, Jäger AK, Meyer JJM, Lall N: Antimicrobial
activity of selected South African medicinal plants. BMC Complementary
and Alternative Medicine 2012, 12:74-80.
- 14. Oztekin N, Baskan S, Kepekci SE, Erim FB, Topcu G: Isolation and
analysis of bioactive diterpenoids in Salvia species (Salvia chionantha
and Salvia kronenburgiii) by micellar electrokinetic capillary
chromatography. Journal of Pharmaceutical and Biomedical Analysis
2010, 51:439-442.
- 15. Azcan N, Ertan A, Demirci B, Baser KHC: Fatty acid composition of
seed oils of twelve Salvia species growing in Turkey. Chemistry of
Natural Compounds 2004, 40(3):218-221.
- 16. Kotan R, Kordali S, Cakir A, Kesdek M, Kaya Y, Kilic H: Antimicrobial
and insecticidal activities of essential oil isolated from Turkish
Salvia hydrangea DC. ex Benth. Biochemical Systematics and
Ecology 2008,36:360-368.
- 17. Kirmizibekmez H, Bardakci Altan H, Liktor-Busa E, Zana A, Yesilada
E, Hohmann J: Chemical constituents of Salvia dichroantha.
Biochemical Systematics and Ecology 2012, 42:18-20.
- 18. Ulubelen A, Topcu G, Chai HB, Pezzuto JM: Cytotoxic activity of
diterpenoids isolated from Salvia hypargeia. Pharmaceutical Biology
1999, 37(2):148-151.
- 19. Temel HE, Demirci B, Demirci F, Celep F, Kahraman A, Doğan M,
Başer KHC: Chemical characterization and anticholinesterase effects
of essential oils derived from Salvia species. Journal of Essential Oil
Research 2016, 28(4): 322-331.
- 20. Alimpić A, Knežević A, Milutinović M, Stević T, Šavikin K, Stajić
M, Marković S, Marin P, Matevski V, Duletić-Laušević S: Biological
activities and chemical composition of Salvia amplexicaulis Lam.
extracts. Industrial Crops & Products 2017, 105:1-9.
- 21. Topcu G, Turkmen Z, Ulubelen A, Schilling JK, Kingston DGI:
Highly Hydroxylated Triterpenes from Salvia kronenburgii. Journal
of Natural Products 2004, 67:118-121.
- 22. Nateche F, Martin A, Baraka S, Palomino JC, Khaled S, Portaels F:
Application of the resazurin microtitre assay for detection of multidrug
resistance in Mycobacterium tuberculosis in Algiers. Journal of
Medical Microbiology 2006, 55:857-860.
- 23. Bahmani M, Zargaran A, Rafieian-Kopaei M, Saki K: Ethnobotanical
study of medicinal plants used in the management of diabetes mellitus in
the Urmia, Northwest Iran. Asian Pacific Journal of Tropical Medicine 2014,
7(Suppl 1):348-354.
- 24. Ersen D, Ulger M, Mangelinckx S, Gemili M, Sahin E, Nural Y:
Synthesis and anti(myco)bacterial activity of novel 5,5- diphenylpyrrolidine
N-aroylthiourea derivatives and a functionalized hexahydro-
1H-pyrrolo[1,2-c]imidazole. Medicinal Chemistry Research
2017, 26:2152-2160.
- 25. NCCLS. Reference Method for Broth Dilution Antifungal Susceptibility
Testing of Yeasts; Approved Standard-Second Edition. NCCLS
document M27-A2 (ISBN 1-56238-469-4). NCCLS, 940 West Valley
Road, Suite 1400, Wayne, Pennsylvania 19087-1898 USA, 2002.
- 26. Sonmez M, Celebi M, Berber I: Synthesis, spectroscopic and
biological studies on the new symmetric Schiff base derived from
2,6-diformyl-4-methylphenol with N-aminopyrimidine. European
Journal of Medicinal Chemistry 2010, 45:1935-1940.
- 27. Guzeldemirci NU, Kuçukbasmacı Ö: Synthesis and antimicrobial
activity evaluation of new 1,2,4-triazoles and 1,3,4-thiadiazoles bearing
imidazo[2,1-b]thiazole moiety. European Journal of Medicinal
Chemistry 2010, 45:63-68.
- 28. Digrak M, Alma MH, Ilcim A: Antibacterial and antifungal activities
of Turkish medicinal plants. Pharmaceutical Biology 2001,
39(5):346-350.
- 29. Pirbalouti AG, Jahanbazı P, Enteshari S, Malekpoor F, Hamedi B:
Antimicrobial activity of some Iranian medicinal plants. Archives of
Biological Science Belgrade 2010, 62(3):633-642.
- 30. Karagoz, Artun FT, Ozcan G, Melikoglu G, Anıl S, Kultur S, Sutlupınar
N: In vitro evaluation of antioxidant activity of some plant
methanol extracts, Biotechnology & Biotechnological Equipment
2015, 29(6):1184-1189.
- 31. Hatipoglu SD, Zorlu N, Dirmenci T, Goren A C, Ozturk T, Topcu G:
Determination of volatile organic compounds in fourty five Salvia
species by Thermal Desorption-GC-MS Technique. Records of
Natural Products 2016, 10(6): 659-700.
- 32. Hatipoglu SD, Yalcinkaya B, Akgoz M, Ozturk T, Goren AC, Topcu
G: Screening of hallucinogenic compounds and genomic characterisation
of 40 Anatolian Salvia species. Phytochemical Analysis 2017,
28:541-549.
- 33. Demirci B, Demirci F, Donmez AA, Franz G, Paper DH, Başer KHC:
Effects of Salvia essential oils on the Chorioallantoic Membrane
(CAM) Assay. Pharmaceutical Biology 2005, 43(8):666-671.
- 34. Sezer Senol F, Orhan I, Celep F, Kahraman A, Dogan M, Yilmaz G,
Sener B: Survey of 55 Turkish Salvia taxa for their acetylcholinesterase
inhibitory and antioxidant activities. Food Chemistry 2010,
120:34–43.
- 35. Kawazoe K, Yamamoto M, Takaishi Y, Honda G, Fujita T, Sezik E,
Yesilada E: Rearranged abietane-type diterpenes from Salvia dichroantha.
Phytochemistry 1999, 50:493-497.
- 36. Topcu G: Bioactive Triterpenoids from Salvia Species. Journal of
Natural Products 2006, 69:482-487.
- 37. Dent M, Dragović-Uzelac, Penić M, Brnĉić, Bosiljkov T, Levaj B:
The effect of extraction eolvents, temperature and time on the composition
and mass fraction of polyphenols in dalmatian Wild Sage
(Salvia officinalis L.) extracts. Food Technology and Biotechnology
2013, 51(1):84-91.
- 38. Kowalczyk D, Świeca M, Cichocka J, Gawlik-Dziki U: The phenolic
content and antioxidant activity of the aqueous and hydroalcoholic
extracts of hops and their pellets. Journal of the Institute of Brewing
2013, 119:103-110.
- 39. Lean SS, Yeo CC: Small, enigmatic plasmids of the nosocomial
pathogen, Acinetobacter baumannii: good, bad, who knows?. Frontiers
in microbiology 2017, 8:1547.