Yeni Modifiye Poli(maleik anhidrid-ko-vinil asetat)/Akriflavin Konjugatının Sentezi, Yapısal Karakterizasyonu ve Suda Çözünürlüğü

Yeni fonksiyonel poli(maleik anhidrit-ko-vinil asetat)/Akriflavin konjugatı, MAVA/AF, iki farklı yolla kopolimer:ilaç oranı sırasıyla 1:1 ve 1:2 olacak şekilde sentezlendi. Konjugasyon tepkimesi için toksik olmayan polimerik ilaç taşıyıcı hazırlandı. Saflaştırılan kopolimer, MAVA, antikanser aktif akriflavin (AF) ajanı ile 60°C’da 72 saat dimetilformamid (DMF) içinde, trietilamin (TEA) katalizörlüğünde modifiye edildi. Yapısal karakterizasyon Fourier Transform Infrared (FTIR) ve Nükleer Magnetik Rezonans (1H-NMR) ile yapıldı. Spektroskopik analiz sonuçları konjugasyon/modifikasyon tepkimesinin başarılı bir şekilde amidleşme reaksiyonu ile olduğunu doğrulamaktadır.

Synthesis, Structural Characterization, and Water Solubility of a Novel Modified Poly(maleic anhydride-co-vinyl acetate)/ Acriflavine Conjugate

Novel functional poly(maleic anhydride-co-vinyl acetate)/acriflavine conjugate, MAVA/AF, was synthesized in two different ways that copolymer:drug ratio was designed as 1:1 and 1:2, respectively. Nontoxic polymeric drug carrier was prepared for conjugation reaction. The purified copolymer, MAVA, was modified with an antiexternal fungal and anticancer active agent acriflavine (AF) at 60°C for 72 hours in dimethylformamide (DMF), using triethylamine (TEA) as the catalyst. Structural characterizations were carried out by Fourier Transform Infrared (FTIR) and Nuclear Magnetic Resonance (1H-NMR). The spectroscopic results confirmed that conjugated/modification reaction was successfully carried out by amidification reaction.

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