Deniz TURKMEN, Ilgım GÖKTÜRK, Adil DENİZLİ, Handan Yavuz ALAGÖZ, Nilay BERELİ, Semra AKGÖNÜLLÜ, Sevgi ASLIYÜCE, Duygu ÇİMEN

Biomimetik Sistemler için Moleküler Bakılama Teknolojisi

Biyomimetik terimi, kısaca doğanın incelenmesi olarak tanımlanabilir. Bilim adamları biyomedikal ve terapötik uygulamalarda, daha iyi ilaçlar, yapay organlar, algılama aletleri vb. yapmak için doğal modelleri, sistemleri ve unsurları taklit ederek, insan sorunlarını çözmek ve günlük yaşamı kolaylaştırmak için doğanın muazzam çeşitliliğinden ilham aldılar. Bu tür uygulamalarda, stabilite ve tekrar kullanılabilirlikteki eksikliklere rağmen, özgüllüğü sağlamak için proteinler, antikorlar, enzimler, DNA, lektinler, aptamerler, hücreler ve virüsler gibi biyolojik tanıma öğeleri yoğun olarak kullanılmıştır. Bununla birlikte, son yirmi yılda moleküler baskılanmış polimerler (MIP’ler), çapraz bağlayıcının varlığında kalıp yapı etrafında fonksiyonel monomerlerin koordine edilmesi yoluyla geniş bir örnek yelpazesi oluşturmuş ve doğal biyolojik etkileşimleri taklit etmeye bir alternatif olarak sentezlenmiştir. Bu derleme, ayırma tekniklerinde, doku mühendisliği uygulamalarında, biyomimetik yüzeylerde, sensörlerde, yapay membranlar ve ilaç taşınım sistemlerinde moleküler baskılama teknikleriyle hazırlanan biyomimetiklerin genel hatlarını ve pratik uygulamalarını özetleyecektir.

Molecular Imprinting Technology for Biomimetic Assemblies

The term biomimetic can be simply defined as the examination of nature. The scientist inspired from the enormous diversityof nature to solve human problems or facilitate the daily life by mimicking natural models, systems and elements especiallyin biomedical and therapeutic applications to make better drugs, artificial organs, sensing instruments etc. Biologicalrecognition elements like proteins, antibodies, enzymes, DNA, lectins, aptamers, cells and viruses have been heavily usedto ensure specificity in such applications in spite of their lack of stability and reusability. However, in the last two decadesmolecularly imprinted polymers, MIPs, have been synthesized as an alternative to mimic natural biological interactions fora broad spectrum of templates by means of coordinating functional monomers around template in the presence of crosslinker. This review will outline the broad contours of biomimetics prepared by molecular imprinting techniques and theirpractical applications in the separation techniques, tissue engineering applications, biomimetic surfaces, sensors, artificialmembranes and drug delivery systems.

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