Seda YÜKSEKDANACI, Demet ASTLEY, İhsan YAŞA

Synthesis, characterization and antimicrobial studies of new chiral amide-Schiff base derivatives

In this study, new chiral Schiff bases (3-9) obtained from the reaction of chiral amide derivatives with different substituted aromatic aldehyde were synthesized. All synthesized compounds structures were characterized by FTIR, 1H-NMR, 13C-NMR and elemental analysis. All of the new synthesized compounds were tested in vitro against Staphylococcus aureus, Bacillus cereus, Escherichia coli, Salmonella thyphimirium, Klebsiella pneumoniae, Enterococcus faecalis, Pseudomonas aeruginosa, Candida albicans for their antibacterial and antifungal activities. All compounds have shown moderate to good antibacterial activity against Gram-positive and Gram-negative bacteria. Among the compounds tested compound 7 showed most potent inhibitory action against test organisms.

Keywords:

amino acid amide, schiff base, antimicrobial,

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