Abdullah KUMRAL, Didem Cemile YEŞİLIRMAK

Fetal Enflamatuar Yanıt Sendromu ve Beyin Zedelenmesi

Preterm doğuma ve neonatal komplikasyonlara neden olan faktörler içerisinde en sık saptanan nedenlerin başında intrauterin enfeksiyonve/veya enflamasyon gelmektedir. Mikroorganizma veya ürünlerinin fetusa ulaşması sitokin salınışına ve sistemik fetal enflamatuar cevaba FIRS neden olmaktadır. FIRS; fetal veya neonatal beyin hasarına neden olarak ileride serebral palsi CP gelişimine yol açmaktadır. intrauterin dönemde sitokinlerin neden olacağı beyaz cevher hasarı ve preterm doğum ile CP arasındaki ilişki günümüzde iyi bilinmektedir. Klinikte karşımıza periventriküler lökomalazi PVL olarak çıkan beyaz cevher hasarı, nörogelişimsel prognoz ve CP’nin ağırlığı açısından oldukça önemlidir. Güncel Pediatri 2007; 5: 25-7

Anahtar Kelimeler:

Fetal enflamatuar yanıt sendromu, beyin hasarı

Fetal Inflammatory Response Syndrome and Brain Damage

Intrauterine infection/inflammation has been identified as the most common cause of preterm delivery and neonatal complications. When microorganisms or their products gain access to the fetus they stimulate the production of cytokines and a systemic response termed FIRS Fetal Inflammatory Response Syndrome . Subsequently, FIRS was implicated as a cause of fetal or neonatal brain injury that leads to cerebral palsy CP . A relationship between CP and intra-amniotic inflammation was demonstrated, intrauterine infection may lead to activation of the cytokine network which in turn can cause white matter brain damage and preterm delivery, as well and as the future development of CP. This white matter insult is identified clinically as periventricular leucomalacia PVL which is associated with the subsequent development of impaired neurological outcomes of variable severity including CP.

Keywords:

Fetal inflammatory response syndrome, brain injury,

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