Çocuklarda Hızlı ve Seri Entübasyon

Hızlı ve seri entübasyon; entübasyonun daha güvenli ve kolay, daha hızlı ve az travmatik yapılmasını sağlamak amacıyla birtakım nöromuskuler blokörlerin ve sedatif ajanların kullanılması suretiyle oluşturulduğu bir yöntemdir. Çocuk acil servislerinde entübasyon gerektiren hastalarda kullanımı giderek yaygınlaşan ve pediatrik resusitasyon kurslarında eğitimi verilen bir yöntem olmaya başlamıştır. Çalışmaların çoğunda hızlı ve seri entübasyonun HSE klasik entübasyon yöntemlerinden daha fazla tercih edildiği görülmüştür. 7000’den fazla hasta içeren geniş bir prospektif çalışmada hastaların %78’inde HSE yönteminin kullanıldığı vurgulanmıştır. HSE, daha başarılı bir yöntem olması nedeniyle genellikle acil servislerde ilk olarak tercih edilmektedir. Nitekim bu farklılık, az sayıda hasta içeren birçok retrospektif ve çok sayıda hasta içeren bir tane prospektif çalışmada açıkça ortaya konulmuştur. HSE, ileri havayolu yönetiminde eğitilmiş ve sedatif paralitik doz bilgisine sahip acil servis pediatristlerinin güvenle uygulayabilecekleri bir yoldur. HSE birçok pediatrik seride ve erişkinlerde yapılmış daha geniş kapsamlı çalışmalarda gösterilmiştir.
Anahtar Kelimeler:

Entübasyon, hızlı, çocuk

Rapid Sequence Intubation in Children

Rapid sequence intubation RSI is a commonly used technique in the emergency department ED to facilitate the placement of an emer- gency airway. This technique is the performance of intubation with sedatives and neuromusculer blockade, with the objective of mak- ing procedure quicker, easier and less traumatic. Patients that are candidates for RSI are all those who require intubation and have vary- ing levels of consciousness and with any suspicion of a full stomach. The Core Content for Emergency Medicine EM recommends that all emergency physicians should be trained to manage the airway, including administering paralytic agents for endotracheal intubation. Emergent intubations can be performed with or without sedation and paralysis. The vast majority are performed using RSI, a specific intubation technique that involves sedation and paralysis, with airway protection. This was demonstrated in a large prospective series including more than 7000 patients, in which 78 percent of intubations were performed using RSI.
Keywords:

Intubation, rapid, child,

___

  • 1. McAllister JD, Gnauck KA. Rapid sequence intubation of the pediatric patient-fundamentals of practice. Pediatr Clin North Am 1999; 46:1249-84.
  • 2. Gerardi MJ, Sacchetti AD, Cantor RM, et al. Rapid-sequence intubation of the pediatric patient. Pediatric Emergency Medicine Committee of the American College of Emergency Physicians. Ann Emerg Med 1996; 28:55-74.
  • 3. Ma Oj, Bentley B 2nd, Debehnke DJ. Airway management practicies in emergency medicine residencies. Am J Emerg Med. 1995; 13:501-4.
  • 4. Rapid Sequence Intubation. In: PALS Provider Manual, American Heart Association, 2002; 359.
  • 5. Sagarin MJ, Barton ED, Chng YM, Walls RM. Airway management by US and Canadian emergency medicine residents: a multicenter analysis of more than 6,000 endotracheal intubation attempts. Ann Emerg Med 2005; 46:328-36.
  • 6. Bair AE, Filbin MR, Kulkarni RG, Walls RM. The failed intubation attempt in the emergency department: analysis of prevalence, rescue techniques, and personnel. J Emerg Med 2002; 23:131-40.
  • 7. Li J, Murphy-Lavoie H, Bugas C, Martinez J, Preston C. Complications of emergency intubation with and without paralysis. Am J Emerg Med 1999; 17:141-3.
  • 8. Brownstein D, Shugerman R, Cummings P, Rivara F, Copass M. Prehospital endotracheal intubation of children by paramedics. Ann Emerg Med 1996; 28:34-9.
  • 9. Syverud SA, Borron SW, Storer DL, et al. Prehospital use of neuromuscular blocking agents in a helicopter ambulance program. Ann Emerg Med 1988; 17:236-42.
  • 10. Gnauck K, Lungo JB, Scalzo A, Peter J, Nakanishi A. Emergency intubation of the pediatric medical patient: use of anesthetic agents in the emergency department. Ann Emerg Med 1994; 23:1242-7.
  • 11. Sagarin MJ, Chiang V, Sakles JC, et al. Rapid sequence intubation for pediatric emergency airway management. Pediatr Emerg Care 2002; 18:417-23.
  • 12. Sakles JC, Laurin EG, Rantapaa AA, Panacek EA. Airway management in the emergency department: a one-year study of 610 tracheal intubations. Ann Emerg Med 1998; 31:325-32.
  • 13. Marvez-Valls E, Houry D, Ernst AA, Weiss SJ, Killeen J. Protocol for rapid sequence intubation in pediatric patients -- a four-year study. Med Sci Monit 2002; 8:229-34.
  • 14. Levitan R, Ochroch EA. Airway management and direct larygoscopy- a review and update. Crit Care Clin 2000; 16:373-88.
  • 15. Benumof JL, Dagg R, Benumof R. Critical hemoglobin desaturation will occur before return to an unparalyzed state following 1 mg/kg intravenous succinylcholine. Anesthesiology 1997; 87:979-82.
  • 16. Luten RC, Kissoon N. Approach to the pediatric airway. In: Manual of emergency airway management, 2nd ed, Walls, RM, Murphy, MF, Luten, RC, et al (Eds), Lippincott Williams and Wilkins, Philadelphia 2004, 212.
  • 17. Patel R, Lenczyk M, Hannallah RS, McGill WA. Age and the onset of desaturation in apnoeic children. Can J Anaesth 1994; 41:771-4.
  • 18. Janssens M, Hartstein G. Manegement of difficult intubation. Eur J Anaesthesiol 2001; 18:3-12.
  • 19. Deem S, Bishop MJ. Evaluation and management of the difficult airway. Crit Care Clin 1995; 1191:1-27.
  • 20. Slater EA, Weiss SJ, Ernst AA, Haynes M. Preflight versus en route success and complications of rapid sequence intubation in an air medical service. J Trauma 1998; 45:588-92.
  • 21. Mazurek AJ, Rae B, Hann S, et al. Rocuronium versus succinylcholine:are they equally effective during rapid-sequence induction of anesthesia? Anesth Analg 1998; 87:1259-62.
  • 22. Cook DR. Can Succinylcholine be abandoned ? Anesth Analg 2000; 90:24-8.
  • 23. Leigh, MD, McCoy, DD, Belton, MK, Lewis GB. Bradycardia following intravenous administration of succinylcholine chloride to infants and children. Anesthesiology 1957; 18:698-702.
  • 24. Sing RF, Reilly PM, Rotondo MF, Lynch MJ, McCans JP, Schwab CW. Out-of-hospital rapid-sequence induction for intubation of the pediatric patient. Acad Emerg Med 1996; 3:41-5.
  • 25. Fastle RK, Roback MG. Pediatric rapid sequence intubation: incidence of reflex bradycardia and effects of pretreatment with atropine. Pediatr Emerg Care 2004; 20:651-5.
  • 26. Zelicof-Paul A, Smith-Lockridge A, Schnadower, D et al. Controversies in rapid sequence intubation in children. Curr Opin Pediatr 2005; 17:355-62.
  • 27. Poulton TJ, James FM3rd. Cough suppresion by lidocaine. Anesth 1979; 50:472.
  • 28. Slater EA, Weiss SJ, Ernst AA, Haynes M. Preflight versus en route success and complications of rapid sequence intubation in an air medical service. J Trauma 1998; 45:588-92.
  • 29. Schneider RE, Caro DC. Pretreatment agents. In: Manual of emergency airway management, 2nd ed, Walls, RM, Murphy, MF, Luten, RC, et al (Eds), Lippincott Williams and Wilkins, Philadelphia 2004. p.187.
  • 30. Yamamato LG. Emergency airway management – rapid sequence intubation. In: Textbook of Pediatric Emergency Medicine, 5th ed, Fleisher, GR, Ludwig, S, Henretig, FM (Eds), Lippincott Williams & Wilkins, Philadelphia, 2006, 81.
  • 31. Bergen JM, Smith DC. A review of ethomidate for rapid sequence intubation in the emergency department. J Emerg Med 1997; 15:221-3.
  • 32. Tayal VS, Riggs RW, Marx JA, Tomazewski CA, Schneider RE. Rapid-sequence intubation at an emergency medicine residency: success rate and advers events during a two- year period. Acad Emerg Med 1999; 6:31-7.
  • 33. Plewa MC, King R, Johnson D, Adams D, Engoren M. Etomidate use during emergency intubation of trauma patients. Am J Emerg Med 1997; 15:98-100.
  • 34. Oglesby AJ. Should etomidate be the induction agent of choice for rapid sequence intubation in the emergency department? Emerg Med J 2004; 21:655-9.
  • 35. Moss E, Powell D, Gibson RM, Mcdowall DG. Effect of etomidate on intracranial pressure and cerebral perfusion pressure. Br J Anaesth 1979; 51:347-52.
  • 36. Modica PA, Tempelhoff R. Intracranial pressure during induction of anaesthesia and tracheal intubation with etomidate-induced EEG burst suppresion. Can J Anaesth 1992; 39:236-41.
  • 37. Kay B. A clinical assessment of the use of etomidate in children. Br J Anaesth 1976; 48:207-11.
  • 38. Kay B. Total intavenous anesthesia with etomidate. II. Evaluation of practical technique for children. Acta Anaesthesiol Belg 1977; 28:115-21.
  • 39. Scheiber G, Riberio FC, Marichal A, Bredendiek M, Renzing K. Intubating conditions and onset of action after rocuronium, vecuronium and atracurium. Anesth Analg 1996; 83:320-4.
  • 40. Ribeiro FC, Scheiber G, Marichal A. Comparison of time course of neuromuscular blockade in young chiuldren following rocuronium and atracurium. Eur J Anaesthesiol 1998; 15:310-3.
  • 41. Noel S. Zuckerbraun, Raymond D. Pietti, et al. Use of etomidate as an induction agent for rapid sequence intubation in a pediatric emergency department. Acad Emerg Med 2006; 13:602-9.
  • 42. Sokolove PE, Price DD, Okada P. Theb safety of etomidate for emergency rapid sequence intubation of pediatric patients. Pediatr Emerg Care 2000; 16:18-21.
  • 43. Schenarts CL, Burton JH, Riker RR. Adrenocortical dysfunction following etomidate induction in emergency department patients. Acad Emerg Med 2001; 8:1-7.
  • 44. Guldner G, Schultz J, Sexton P, et al. Etomidate for rapid –sequence intubation in young children: hemodynamic effects and adverse events. Acad Emerg Med 2003; 10:134-9.
  • 45. Sagarin MJ, Barton ED, Sakles JC, Vissers RJ, Chiang V, Walls RM; National Emergency Airway Registry Investigators. Underdosing of midazolam in emergency endotracheal intubation. Acad Emerg Med 2003; 10:329-38.
  • 46. Sivilotti ML, Filbin MR, Murray HE, et al. Does the sedative agent facilitate emergency rapid sequence intubation. Acad Emerg Med 2003; 10:612-20.
  • 47. Purcell-Jones G, Yates A, Baker J, James I. Comparision of the induction characteristics of thiopentone and propofol in children. Br J Anaesth 1987; 59:1431-6.
  • 48. Aun C, Sung R, O’ Meara, et al. Cardiovascular effects of i.v. induction in children: comparision between propofol and thiopentone. Br J Anaesth 1993; 70:647-53.
  • 49. White PF. Comperative evaluation of intravenous agents for rapid sequence induction-thiopental, ketamine, and midazolam. Anesth 1982; 57:279-82.
  • 50. Hemming A, MacKenzie I, Finfer S. Response to ketamine in status asthmaticus resistant to maximal medical treatment . Thorax 1994; 49:90-1.
  • 51. Hemmingsen C, Nielsen PK, Odorico J. Ketamine in the treatment of bronchospasm during mechanical ventilation. Am J Emerg Med 1994; 12:417-20.
  • 52. Dahlbacka S, Makela J , Kaakinen T, et al. Propofol is associated with impaired brain metabolism during hypothermic circulatory arrest: An experimental microdialysis study. The Heart Surgery Forum 2006; 9:710-8.
  • 53. Morel D, Forster A, Gardaz JP, Suter PM, Gemperle M. Comparative haemodynamic and respiratory effects of midazolam and flunitrazepam as induction agents in cardiac surgery. Arzneimittelforschung 1981; 31:2264-7.
  • 54. Vilke GM, Sharieff GO, Marino A, Gerhart AE. Midazolam for the treatment of out-of-hospital pediatric seizures. Prehosp Emerg Care 2002; 6:215-7. Saz ve ark. Çocuklarda H›zl› ve Seri Entübasyon Güncel Pediatri 2007; 5: 11-7 16 GüncelPediatri
  • 55. Griner RL 2nd, Tobin JR. Probable succinylcholine-induced hyperkalemia in a trauma victim after recent benign anesthesics with succinylcholine. CRNA 1994; 5:151-5.
  • 56. Thapa S, Brull SJ. Succinylcholine-induced hyperkalemia in patients with renal failure: an old question revisited. Anesth Analog 2000; 91:237-41.
  • 57. Martyn JA, Richtsfeld M. Succinylcholine-induced hyperkalemia in acquired pathologic states: etiologic factors and molecular mechanisms. Anesthesiology 2006; 104:158-69.
  • 58. Berahn JM, Sleigh JW. Hyperkalaemic cardiac arrest following succinylcholine in a longterm intensive care patient. Anaesth Intensive Care 1997; 25:588-9.
  • 59. Chakravarty EF, Kirsch CM, Jensen WA, et al. Cardiac arrest due to succinylcholine-induced hyperkalemia in a patient with wound botulism. J Clin Anesth 2000; 12:80-2.
  • 60. Kovarik WD, Morray JP. Hyperkalemic cardiac arrest after succinylcholine administration in a child with purpura fulminans. Anesthesiology 1995; 83:211-3.
  • 61. Kerr TP, Duward A, Hodgson SV,et al. Hyperkalaemic cardiac arrest in a manifesting carrier of Duchenne muscular dystrophy following genereal anaesthesia. Eur J Pediatr 2001; 160:579-80.
  • 62. Larach MG, Rosenberg H, Gronert GA, et al. Hyperkalemic arrest during anesthesia in infans and children with occult myopathies. Clin Pediatr 1997; 36:9-16.
  • 63. Schulte – Sasse U, Eberlei HJ, Schmucker I, et al. Should the use of succinylcholine in pediatric anesthesia be re-evaluated? Anaesthesiol Reanim 1993; 10:13-19.
  • 64. Sullivan M, Thompson WK, Hill GD. Succinylcholine-induces cardiac arrest in children with undiagnosed myopathy. Can J Anaesth 1994; 41:497-501.
  • 65. Wadbrook PS. Advances in airway pharmacology. Emerging trends and evolving controversy. Emerg Med clin North Am 2000; 18:767- 88.
  • 66. Wierda JM, de Wit AP, Kuizenga K, Agoston S. Clinical observations on the neuromuscular blocking action of Org 9426, a new steroidal nondepolarizan agent. Br Anaesth 1990; 64:521-3.
  • 67. Booij LH, Knape HT. The neuromuscular blocking effect of Org 9426. A new intermediately –actingsteroidal nondepolarising muscle relaxant in man. Anaesthesia 1991; 46:341-3.
  • 68. Magorian T, Flannery KB, Miller RD. Comparision of rocuronium, succinylcholine, and vecuronium for rapid-sequence induction of anesthesia in adult patients. Anesthesiology 1993; 79:913-18.
  • 69. Sparr HJ, Luger TJ, Heidegger T, et al. Comparision of intubating conditions after rocuronium and suxamethonium following’rapidsequnce induction’ with thiopentone in elective cases. Acta Aanaesthesiol Scand 1996; 40:425-30.
  • 70. McCourt KC, Salmela L, Mirakhur RK, et al. Comparision of rocuronium and suxamethonium for use during rapid sequence induction of anaesthesia. Anaesthesia 1998; 53:867-71.
  • 71. Andrews JI, Kumar N, van den Brom RHG, et al. A large simple ramdomized trial of rocuronium versus succinylcholine inrapid-sequence induction of anesthesia along with propofol. Acta Anaesthesiol Scand 1999; 43:4-8.
  • 72. Naguib M, Samarkandi AH, Ammar A, et al. Comparision of suxamethonium and different combinations of erocuronium and mivacurium for rapid tracheal intubation in children. Br J Anaesth 1997; 79:450-5.
  • 73. Medina FA. Rapid sequence induction/intubation using intraosseous infusion of vecuronium bromide in children. Am J Emerg Med 1992; 10:359-60.