Suçiçeği ile ilişkili Stevens-Johnson sendromu

Stevens-Johnson Sendromu, deri ve mukozaları tutan, hedef lezyonlar ve büllerle seyreden, hayatı tehdit edebilen, akut bir aşırı duyarlılık reaksiyonudur. Klinik bulgular hafif deri ve müköz membran tutulumu ile ağır sistemik bozukluklar arasında değişkenlik gösterir. Stevens-johnson sendromunun bilinen en yaygın nedenleri; ilaçlar, aşılar ve viral enfeksiyonlardır. Bu makalede 9 yaşında, suçiçeği ile birlikte Stevens-Johnson sendromu gelişen bir olgu sunuluyor. Olgumuzda asiklovir ve intravenöz immünoglobulin teda- visi ile klinik bulguların düzeldiğini ve gelişebilecek komplikasyonların kontrol altına alındığını görüyoruz

Stevens-Johnson syndrome associated with varicella infection

Stevens-Johnson syndrome, is an acute hypersensitivity reaction that involves skin and mucous membranes, develops with target lesions and bullous lesions, and can be life threatening. Clinical findings range from mild skin and mucous membrane involvement to severe systemic disorders. Drugs, vaccines and viral infections are the most commonly known causes of Stevens-Johnson syndrome. In this article, a 9 year old case that developed Stevens-Johnson syndrome along with varicella is presenting. With acyclovir and int- ravenous immunoglobulin treatment clinical findings improved and development of complications is controlled

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Morelli JG. Stevens-Johnson Syndrome. In: Kliegman RM, Stanton BF, Schor NF, Geme JW, Behrman RE. Nelson Textbook of Pediat- rics 19th Edition. Elsevier, 2011; 2242-3.
Stitt VJ Jr. Stevens-Johnson syndrome: A review of the literature. J Natl Med Assoc 1988;80:104-8.
Bay A, Akdeniz N, Calka O, et al. Primary varicella infection asso- ciated with Stevens-Johnson syndrome in a Turkish child. J Der- matol 2005;32:745-50.
de Ru MH, Sukhai RN. Stevens-Johnson syndrome. Eur J Pediatr 2007;166:1303-4.
Mulvey JM, Padowitz A, Lindley-Jones M, et al. Mycoplasma pneu- moniae associated with Stevens Johnson syndrome. Anaesth Inten- sive Care 2007;35:414-7.
Wetter DA, Camilleri MJ. Clinical, etiologic, and histopathologic features of Stevens-Johnson syndrome during an 8-year period at Mayo Clinic. Mayo Clin Proc 2010;85:131-8.
Tripathi A, Ditto AM, Grammer LC, et al. Corticosteroid therapy in an additional 13 cases of Stevens-Johnson syndrome: a total se- ries of 67 cases. Allergy Asthma Proc 2000;21:101-5.
Patterson R, Dykewicz MS, Gonzalzles A, et al. Erythema multi- forme and Stevens-Johnson syndrome. Descriptive and therapeutic controversy. Chest 1990;98:331-6.
Dalli RL, Kumar R, Kennedy P, et al. Toxic epidermal necrolysis/ Stevens-Johnson syndrome: current trends in management. ANZ J Surg 2007;77:671-6.
Prins C, Vittorio C, Padilla RS, et al. Effect of high-dose intrave- nous immunoglobulin therapy in Stevens-Johnson syndrome: a retrospective, multicenter study. Dermatology 2003;207:96-9.