Helikobakter pilori enfeksiyonu Mikozis fungoides için risk faktörü müdür?

Giriş: Kutane T hücreli lenfomalar (KTHL)'ın iki önemli varyantı; Mikozis fungoides ve Sezary sendromudur. KTHL'ın oluşumun- daki, otolog dendiritik hücrelerin, tümöral yöndeki dönüşümlerini, hangi antijenlerin başlattığı bilinmemektedir. Helicobacter py- lori'nin (H.pylori) bazı dermatozlarla ilişkili olduğu bilinmektedir. H.pylori; kronik gastrit, peptik ülser ve gastrik mukoza ilişkili lenfoid doku lenfomanın (MALT) gastrik B hücreli lenfoması ile kuvvetle ilişkili gram (-) bakteridir. Bu çalışmada H.pylori enfeksi- yonu ile MF gelişimi arasındaki ilişkiyi değerlendirmeyi amaçladık. Gereç ve yöntem: Bu çalışma yaş-cinsiyet eşlemeli vaka-kontrol çalışmasıdır. MF'i olan 50 olgunun 37 (%74)'si evre1 ((n=13 (%26) evre1A) (n=24 (%48) evre 1B)), 13 (%26)'ü evre 2A'ıydı. H.pylori enfeksiyonu ile ilişkisiz dermatolojik hastalığı bulunan 50 olgu kontrol olguları olarak alındı. H.pylori için H. pylori gayta antijen tes- tiyle bakıldı. Bulgular: MF olgularının ortanca yaşı 48 (38.75-59.25), kontrol olgularının ortanca yaşı 53 yıldı. MF olgularının ortalama hastalık süresi 7 yıldı. MF ve kontrol olgularının yaş ve cinsiyet açısından aralarında fark saptanmadı. MF olguları- nın 12 (%24)'sinde H.pylori gayta antijen test (+) idi. Cinsiyet (p=0.185), evre ( p=0.1570), hastalık süresi (p=0.846) ile H.pylori (+) 'liği arasında fark saptanmadı. MF ve kontrol olgularının H.pylori gayta antijen (+)'liği arasında fark saptanmadı (p=0.648). Sonuç: Çalışmamızda H.pylori enfeksiyonu ile MF arasında ilişki saptanmadı. Farklı toplumlarda prospektif, multimerkez çalışmaların ya- pılmasının faydalı olacağını, H.pylori antijeninin MF olgularının MF lezyonu olan dokusunda bakılmasının olası ilişkiyi araştırmada yardımcı olabileceğini düşünmekteyiz

Is Helicobacter pylori infection a risk factor for Mycosis fungoides ?

Objectives: The most common forms of Cutaneous T-cell lymphomas (CTCL) are Mycosis fungoides (MF) and Sezary Syndrome (SS). Etiology of triggering antigenic stimulation causes to form clonal T cell proliferation is not clear. Helicobacter pylori (H.pylori) known to be associated some dermatologic disorders. H.pylori causes primary gastric B cell lymphoma of MALT-type by chronic antigenic stimulation forming clonal proliferation. We evaluated the relationship between H. pylori infection and the development of MF. Materials and methods: This is a sex-age matched case-control study. We studied 50 MF patient, 37 (%74) patient were stage 1 (n=13 (%26) stage 1A) (n=24 (%48) stage 1B), 13 (%26) patient were stage 2A. 50 controls have other dermatologic disorders without any relation between H. pylori infection and their dermatologic disorder. H.pylori infection detected with H. pylori stool antigen. Results: Median age for MF patients were 48 (38.75-59.25). Median age for controls were 53 . Mean MF disease duration was 7 year. There is no difference between ages and sex of MF and controls. 12 (%24) of MF patient have (+) results for H.pylori stool antigen. There is no difference for H. pylori (+) results with sex (p=0.185), stage( p=0.1570) and disease duration (p=0.846). MF and control patients have no difference for H. pylori stool antigen (+) results (p=0.648). Conclusion: Our study did not confirm the relationship between H.pylori infection and MF. We suggest that investigators should plan prospective multicenter studies in different populations. Investigation for antigenic stimulation of H.pylori antigen may be looked in MF tissues

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