Osman BAŞPINAR, Yasin ŞİMŞEK, Derya KOÇER, Oğuzhan Sıtkı DİZDAR, Hatice KAYIŞ TOPALOĞLU

PCOS Patofizyolojisinde Serum R-Spondin-1'in Bir Rolü Var mıdır?

Amaç: Pek çok yeni inflamatuar ve metabolik belirtecin Polikistik Over Sendromu (PCOS) etiyolojisinde rol oynadığı düşünülmektedir. R-spondin-1 (Rspo1), tepe tabakaya özgü spondin protein ailesinin bir üyesidir. Rspo1 seviyeleri obezite ve insülin direnci ile ilişkilendirilmiştir. Rspo1'in PCOS patofizyolojisinde rolü olup olmadığını araştırmayı amaçladık. Gereç ve Yöntem: Bu kesitsel çalışma, yeni tanı konmuş ve tedavi edilmemiş PCOS olguları ve PCOS'u olmayan bir kontrol grubu ile planlandı. PCOS'lu hastalar ve sağlıklı katılımcılar, Rspo1 seviyeleri için karşılaştırıldı. Ayrıca PCOS grubu vücut kitle indeksi (VKİ) ve Ferriman Gallwey skorlarına (FGS) göre de gruplandırılarak Rsop1 düzeyleri açısından karşılaştırıldı. Bulgular: PCOS grubunda 47, kontrol grubunda 36 olmak üzere toplam 83 katılımcı çalışmaya dahil edildi. PCOS ve kontrol grupları benzer yaş ve VKİ'ye sahipti. Kontrol grubu ile karşılaştırıldığında, PCOS hastalarının FGS, insülin direnci skorlarının homeostaz modeli değerlendirmesi, Rspo1 ve toplam testosteron düzeyleri anlamlı olarak daha yüksekti (sırasıyla p

Anahtar Kelimeler:

R-spondin-1, Polikistik over sendromu, Ferriman Gallwey skorları

Does Serum R-Spondin-1 Play a Role in PCOS Pathophysiology?

Objective: Many new inflammatory and metabolic markers are considered to be involved in etiology of Polycystic ovary syndrome (PCOS). R-spondin-1 (Rspo1) is a member of the roof plate-specific spondin protein family. Rspo1 levels have been associated with obesity and insulin resistance. We aimed to investigate whether Rspo1 has a role in the pathophysiology of PCOS. Materials and Methods: This cross-sectional study was planned with newly diagnosed and untreated PCOS cases and a control group without PCOS. Patients with PCOS and healty participants were compared for Rspo1 levels. In addition, the PCOS group was also grouped according to body mass index (BMI) and Ferriman Gallwey scores (FGS) and compared in terms of Rsop1 levels. Results: A total of 47 patients in the PCOS group and 36 participants in the control group, as total 83 participants were included in the study. PCOS and control groups had similar age and BMI. As compared to the control group, PCOS patients had significantly higher FGS, homeostasis model assessment of insulin resistance scores, Rspo1, and total testosterone levels (p

Keywords:

R-spondin-1, Polycystic ovary syndrome, Ferriman Gallwey scores,

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