Halef Okan DOĞAN, Fahrettin BOSTANCI, Ahmet KARADAĞ

Non-farmakolojik Kombine Tedavi Yöntemlerinin Fibromiyaljili Hastalarda Serum Beta-Endorfin Düzeyi, Ağrı, Depresyon, Uyku Kalitesi ve Fonksiyonel Durum Üzerine Etkisi

Amaç: Bu çalışmanın amacı FMS tedavisinde kullanılan non-farmakolojik kombine tedavi metodlarının etkinliğini serum β–Endorfin, ağrı, depresyon, uyku kalitesi ve fonksiyonel durumu değerlendirerek karşılaştırmaktır. Yöntemler: Çalışmaya FMS tanısı almış 60 kadın hasta ve 30 sağlıklı kadın gönüllü dahil edildi. FMS'li hastalar rastgele 30 kişiden oluşan iki eşit gruba ayrıldı. İlk hasta grubuna fizik tedavi ve balneoterapi uygulanırken, ikinci gruba fizik tedavi, balneoterapi ve aerobik egzersiz programı uygulandı. FMS hastaları tedavi öncesi ve sonrası, ağrı için Görsel Analog Skala (GAS), Fibromiyalji Etki Anketi (FEA), Beck Depresyon Ölçeği (BDÖ) ve Pittsburgh Uyku Kalitesi İndeksi (PUKİ) anketleriyle değerlendirildi. Serum β-Endorfin seviyeleri, sağlıklı kontrol grubunda bir kez, FMS hastalarında tedavi öncesi ve sonrası iki kez ölçüldü. Bulgular: FMS’li hasta gruplarında β-Endorfin düzeyi sağlıklı kontrol grubuna göre daha düşüktü ve bu istatistiksel olarak anlamlıydı (p

Anahtar Kelimeler:

Fibromyalji, aerobik egzersiz, balneoterapi, fizik tedavi, tedavi

The Effect of Non-pharmacological Combine Treatment Methods on Serum Beta-Endorphin Level, Pain, Depression, Sleep Quality and Functional Status in Patients with Fibromyalgia

Abstract Objective: This study aims to compare the effectiveness of non-pharmacological combined treatment methods used in Fibromyalgia syndrome (FMS) treatment by evaluating serum β -Endorphine, pain, depression, sleep quality and functional status. Methods: The study included 60 patients diagnosed with FMS and 30 healthy female volunteers. The patients with FMS were divided into two equal groups of 30 subject. The first group of patients received physical therapy and balneotherapy, while the second group received physical therapy, balneotherapy and aerobic exercise program. FMS patients evaluated before and after treatment, by Visual Analogue Scale for Pain (VAS), Fibromyalgia Impact Questionnaire (FIQ), Beck Depression Scale (BDI) and Pittsburgh Sleep Quality Index (PSQI) questionnaires. Serum β-Endorphin levels were measured once in the healthy control group and twice before and after treatment in FMS patients. Results: The β-Endorfin level was lower in both FMS groups than the control group and this was statistically significant (p

Keywords:

Fibromyalgia, aerobic exercise, balneotherapy, physical therapy, treatment,

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