Mehmet ÜNAL, Hüseyin TOL, Şükrü BALEVİ, Gülbahar Ürün UNAL

Mikozis fungoides tedavisinde dbUVB ve PUVA: Retrospektif değerlendirme

Mikozis fungoides (MF)'de darband UVB (dbUVB) ve psoralen+UVA (PUVA) tedavilerinin etkinlikleri karşılaştırmalı şekilde değerlendirildi. Gereç ve yöntem: MF tanısıyla takipli ve dbUVB ve PUVA tedavisi alan 61 hasta retrospektif olarak değerlendirildi. Hastaların cinsiyet, yaş, ek hastalık, tanı zamanı, başlangıç lezyonları, şikayet başlangıcı ile tanı zamanı arası süre, hastalık evresi, lenfadenopati varlığı, verilen fototerapi türü, varsa kombine olarak verilen sistemik tedaviler, remisyona ulaşan hastalarda remisyona kadar olan süre, seans ve doz, idame tedavi süreleri, remisyona ulaşıldıktan sonraki takip süreleri ve remisyon süreleri, nüks durumları ve nüks olan hastalarda remisyon ile nüks arası süre, toplam takip süreleri, toplam verilen PUVA ve dbUVB dozları, yan etkiler ile ilgili bilgiler kaydedildi. Bulgular: DbUVB ve PUVA'nın erken evre MF'de benzer etkinliğe sahip olduğunu tespit ettik.Tam remisyona ulaşma süresi ve tam remisyon relaps arası sürenin dbUVB grubunda daha kısa olduğunu gözlemledik.Tam remisyon oranı evre 2A'da daha düşüktü.Kombinasyon tedavilerinin fototerapi sonuçlarını anlamlı bir şekilde değiştirmediği gözlemlendi. Sonuç: Çalışmamızda dbUVB ve PUVA'nın erken evre MF'te kullanışlı ve kabul edilebilir başarılı sonuçlara ulaştığını. tam remisyona ulaşma süresi ve tam remisyon relaps arası sürenin dbUVB grubunda daha kısa olduğunu gözlemledik

NB-UVB and PUVA in mycosis fungoides therapy: A retrospective study

The efficiency of narrowband UVB (NB-UVB) and psoralen+UVA ( PUVA) in treatment of MF was evaluated. Material and methods: Sixy-one patients diagnosed with MF treated with NBUVB or PUVA were studied retrospectively. Gender, age, time of diagnose, duration from initial lesion/lesions to diagnose and treatment, lypmhadenopathy, MF stage, phototherapy regime, systemic agents, mean time to complete remission (CR), mean number of treatment to CR, mean irradiation dose to CR, mean duration of maintenance therapy, mean relapse-free interval, relapse rate, total follow-up duration, advers effects during treatment and comor- bidities obtained from patients dermatological charts were recorded. Results: Our results indicate that NB-UVB and PUVA have similar conclusions in treatment of early-stage MF. Mean time to CR and mean duration from CR to relapse were shorter for patients who treated with NB-UVB than PUVA group. CR rate was lower in stage 2A. Combination of systemic agents with phototherapy did not have a statistically significant impact as expected. Conclusion: At the end of the our study, we observed that NB-UVB and PUVA are usefull and have acceptably good results in patients with early-stage MF. Mean time to CR and mean duration from CR to relapse were shorter for NB-UVB group

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