BUĞRA KAYA, Zeki DOSTBİL, Murat İSMAİLOĞLU, Mustafa SERDENGEÇTİ

FDG-PET/BT ile tespit edilen küçük hücreli akciğer kanserinin kemik iliği metastazı

Öksürük, hemoptizi, kilo kaybı, yaygın kemik ağrısı şikayetleri ile başvuran elli dokuz yaşında erkek hastanın kontrastlı toraks BT'sin- de sağ akciğerde kitle tespit edildi. Kitlenin biopsi sonucu küçük hücreli akciğer kanseri (KHAK) olarak rapor edildi. Yaygın kemik ağrısı şikayeti olan hastanın kemik sintigrafisi normal olarak değerlendirildi. Evreleme amacıyla yapılan FDG-PET/BT'de kemik ili- ğinde heterojen artmış FDG (florodeoksi glukoz) tutulumu saptandı. Kemik iliği biyopsisinin patolojik değerlendirme sonucu KHAK metastazı olarak raporlandı. Klinik olarak kemik metastazı şüphesi bulunan ve kemik sintigrafisi normal olan hastalarda kemik ve kemik iliği metastazlarını göstermek için FDG-PET/BT görüntüleme akılda tutulmalıdır

Bone marrow metastasis of small cell lung cancer detected by FDG-PET/CT scan: a case report

A mass in the right lung was detected with the contrast enhanced tomography of a fifty-nine year-old male patient presented with cough, hemoptysis, weight loss and common bone pain complaints. The result of the biopsy of the mass was reported as small cell lung cancer (SCLC). Bone scintigraphy of the patient with common bone pain was evaluated as normal. FDG-PET/CT performed for staging revealed heterogeneously increased FDG involvement in the bone marrow. The pathological evaluation result of the bone marrow biopsy was reported as SCLC metastasis. FDG-PET/CT imaging should be kept in mind to show bone and bone marrow metastases in the patients clinically suspected of having bone metastasis and with normal bone scintigraphy

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American Cancer Society. Cancer Facts & Figures 2007; Atlanta, GA: American Cancer Society 2007.
Dunagan D, Chin R Jr, McCain T, et al. Staging by PET predi- cts survival in patients with non small cell lung cancer. Chest 2001;119:333-9.
Clark R, Ihde DC. Small-cell lung cancer: treatment progress and prospects. Oncology (Williston Park) 1998;12:647-58; discussion 61-3.
Schumacher T, Brink I, Mix M, et al. FDG-PET imaging for the staging and follow-up of small cell lung cancer. Eur J Nucl Med 2001;28:483-8.
Abrams J, Doyle LA, Aisner J. Staging, prognostic factors, and special considerations in small cell lung cancer. Semin Oncol 1988;15:261-77.
Jelinek JS, Redmond J, 3rd, Perry JJ, et al. Small cell lung cancer: staging with MR imaging. Radiology 1990;177:837-42.
Hauber HP, Bohuslavizki KH, Lund CH, et al. Positron emission tomography in the staging of small-cell lung cancer : a preliminary study. Chest 2001;119:950-4.
Shen YY, Shiau YC, Wang JJ, Ho ST, Kao CH. Whole-body 18F-2-deoxyglucose positron emission tomography in primary staging small cell lung cancer. Anticancer Res 2002;22:1257-64.
Chin R Jr, McCain TW, Miller AA, et al. Whole body FDG-PET for the evaluation and staging of small cell lung cancer: a preliminary study. Lung Cancer 2002;37:1-6.
Brink I, Schumacher T, Mix M, et al. Impact of [18F]FDG-PET on the primary staging of small-cell lung cancer. Eur J Nucl Med Mol Imaging 2004;31:1614-20.
Kut V, Spies W, Spies S, Gooding W, Argiris A. Staging and moni- toring of small cell lung cancer using [18F]fluoro-2-deoxy-D-glu- cose-positron emission tomography (FDG-PET). Am J Clin Oncol 2007;30:45-50.
Vinjamuri M, Craig M, Campbell-Fontaine A, et al. Can positron emission tomography be used as a staging tool for small-cell lung cancer? Clin Lung Cancer 2008;9:30-4.
Fukuchi K, Yamaguchi M, Hayashida K, Ishida Y. Discrepancy between Tc-99m HMDP bone scan and F-18 FDG positron emis- sion tomographic images in a patient with small cell lung cancer. Clin Nucl Med 2003;28:232-3.
Lin EC, Alavi A. PET and PET/CT: a clinical guide. 2nd ed. New York: Thieme Medical Publishers, 2009;64.
Selcukbiricik F, Yildiz O, Yilmaz S, et al. Increasing role of FDG- PET/CT in detecting bone marrow metastasis of solid tumors in adults: an analysis of ten patients. World J Oncol 2012;3:271-9.