Meme dokusunda tek taraflı Tc-99m perteknetat tutulumu: Laktas- yon dönemindeki bir hastada nadir patern

Meme dokusunda tek taraflı Tc-99m perteknetat tutulumu en sık meme karsinomu ile fibroadenom gibi meme hastalıklarında izle- nir. Meme dokusundaki Tc-99m perteknetat tutulumu, transmembrenal yerleşimli bir protein olan sodyum/iyot taşıyıcı proteinine bağlıdır. Bu proteinin ekspresyonu laktasyonda artar. Bu vaka takdiminde, tiroid sintigrafisinde saptanan ve tek taraflı olarak meme dokusunda Tc-99m perteknetat tutulumu gösteren, laktasyon dönemindeki bir hasta sunulmuştur

Unilateral Tc-99m pertechnetate uptake of breast tissue: Unusual pattern in a lactating patient

Common causes of unilateral breast uptake of Tc-99m pertechnetate are breast carcinoma and benign breast diseases like fibroadeno- ma. Uptake of Tc-99m pertechnetate into the breast tissue depends on transmembrane sodium/iodide symporter and the expression of this protein is enhanced during lactation. In this case report, we present a postpartum patient with unilateral breast uptake of Tc- 99m pertechnetate which was detected during thyroid scintigraphy

___

Moon DH, Lee SJ, Park KY et al. Correlation between 99m Tc-per- technetate uptakes and expressions of human sodium iodide sym- porter gene in breast tumor tissues. Nucl Med Biol 2001;28:829-34.

De Geeter F, Goethals L. Unilateral breast uptake of 99mTc-perte- chnetate. Hell J Nucl Med 2011;14:76-7.

Tazebay UH, Wapnir IL, Levy O et al. The mammary gland iodi- de transporter is expressed during lactation and breast cancer. Nat Med 2000;6:871-8.

Rillema JA, Yu TX, Jhiang SM. Effect of prolactin on sodium iodide symporter expression in mouse mammary gland explants. Am J Physiol Endocrinol Metab 2000;279:E769-72.

Berger F, Unterholzner S, Diebold J et al. Mammary radioiodine accumulation due to functional sodium iodide symporter expres- sion in a benign fibroadenoma. Biochem Biophys Res Commun 2006;349:1258-63.

Bakheet SM, Hammami MM. Patterns of radioiodine uptake by the lactating breast. Eur J Nucl Med 1994;21:604-8.

Gronwald F, Palmedo H, Biersack HJ. Unilateral 131I uptake in the lactating breast. J nucl med 1995;36:1724-5.

Chew CG, Sotiropoulos P. Uptake of Tc-99m pertechnetate by lac- tating breasts during a thyroid scan in a postpartum patient. Clin Nucl Med 2003;28:441-2.

Shankaramurthy G, Bhattacharya A, Kamaleshwaran KK et al. Unilateral breast uptake of Tc-99m pertechnetate in a patient with cold nodule of the thyroid. World J Nucl Med 2012;11:79-80.

Tiktinsky E, Horne T, Agranovich S et al. Unilateral Tc-99m pertechnetate breast uptake: is it always benign? Clin Nucl Med 2007;32:735-6.
Genel Tıp Dergisi-Cover
  • ISSN: 2602-3741
  • Yayın Aralığı: 6
  • Başlangıç: 1997
  • Yayıncı: SELÇUK ÜNİVERSİTESİ > TIP FAKÜLTESİ