Hasan ÖNNER, Farise YILMAZ, Halil ÖZER, Abdussamet BATUR, Gonca KARA GEDİK

Küçük Hücreli Akciğer Kanserinin Beyin Metastazlarının 18F-FDG PET/CT'deki Görünümleri

Amaç: Çalışmamızda, küçük hücreli akciğer kanserinin (KHAK) beyin manyetik rezonans görüntüleme (MRG) ile tespit edilen beyin metastazlarının (BM'ler) 18Fluor-Florodeoksiglukoz (18F-FDG) pozitron emisyon tomografisi/bilgisayarlı tomografisindeki (PET/BT) görünümlerini değerlendirdik. Hastalar ve yöntem: Çalışmaya ilk evreleme amacıyla 30 gün içinde 18F-FDG PET/CT taraması ve beyin MRG'si olan SCLC hastaları dahil edildi. Beyin metastazlarını saptamak için MRG kullanıldı. BM'lerin 18F-FDG PET/BT üzerindeki görüntüleme bulguları değerlendirildi. 18F-FDG PET/BT çalışmasında BM'ler; saptanamayan, hipometabolik, hipermetabolik veya karışık (hem hipermetabolik hem de hipometabolik kısımları olan lezyonlar) paternler olarak sınıflandırıldı. Bulgular: Çalışmaya yaş ortalaması 62.57 ± 9.64 olan 48'i (%94.1) erkek, 3'ü (%5.9) kadın; toplam 51 hasta dahil edildi. Hastaların 15'i (%29,4) sınırlı evredeyken, 36'sı (%69,6) yaygın evredeydi. 11 kişide, beyin MRG 28 BM gösterdi. 18F-FDG PET/BT'de 28 metastazın 13'ü görüldü. 18F-FDG PET/BT'deki BM görünümleri şunlardı: hipometabolik (n: 4), hipermetabolik (n: 6) ve karışık (n: 3). 18F-FDG PET/BT'de saptanan BM'lerin ortalama çapı 16mm iken; saptanamayanların ortalama çapı 4,3 mm idi. Sonuç: 18F-FDG PET/BT'de BM'ler hipometabolik, hipermetabolik ve karışık paternler dahil olmak üzere çeşitli görünümlere sahip olabilir. Öte yandan, 18F-FDG PET/BT ile milimetrik boyutlu BM'lerin saptanamaması evrelemenin düzgün yapılmasını engellemektedir.

Anahtar Kelimeler:

küçük hücreli akciğer kanseri, pozitron emisyon tomografisi, beyin metastazı

The Appearances of Brain Metastases of Small Cell Lung Cancer on 18F-FDG PET/CT

Purpose: We evaluate the appearances of the brain metastases (BMs) detected by brain magnetic resonance imaging (MRI) of small cell lung cancer (SCLC) on 18Fluor-Fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). Patients and methods: SCLC patients who had an 18F-FDG PET/CT scan and a brain MRI within 30 days for initial staging were included. MRI was used to detect BMs. The imaging results of BMs on 18F-FDG PET/CT were assessed. On the 18F-FDG PET/CT study, the BMs were classified as undetectable, hypometabolic, hypermetabolic, or mixed patterns (lesions with both hypermetabolic and hypometabolic parts). Results: A total of 51 patients [48 (94.1%) of whom were male and 3 (5.9%) female, with an average age of 62.57 ± 9.64] were included in this study. Fifteen patients (29.4%) were in the limited stage, whereas 36 patients (69.6%) were in the extensive stage. In 11 individuals, MRI indicated 28 BMs. On 18F-FDG PET/CT, 13 of the 28 metastases were visible. The following were the BMs appearances on 18F-FDG PET/CT: hypometabolic (n: 4), hypermetabolic (n: 6), and mixed (n: 3). While the mean diameter of BMs detected in 18F-FDG PET/CT was 16mm; the mean diameter of undetected ones was 4.3 mm. Conclusion: On 18F-FDG PET/CT, BMs can have a variety of appearances, including hypometabolic, hypermetabolic, and mixed patterns. On the other hand, failure to detect millimetric size BMs in 18F-FDG PET/CT prevents proper staging.

Keywords:

small cell lung cancer, positron emission tomography, brain metastasis,

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