Koroner arter hastalığı ve Chlamydia pneumoniae
Amaç: Son yıllarda yapılan bazı çalışmalar aterosklerozun bazı bakteriyel ve viral etkenlerle ilişkili olabileceğini düşündürmektedir. Bu çalışmada Chlamydia pneumoniae (C. pneumoniae) infeksiyonu ile aterosklerotik koroner arter hastalığı (KAH) arasında bir bağlantı olup olmadığının araştırılması amaçlandı. Yöntem: Koroner arter hastalığı tanısı konan 21 hasta ve 17 sağlıklı birey bu vaka-kontrol çalışmasına dahil edildi. Hastalardan koroner arter bypass greft cerrahisi öncesi venöz kan alındı. Hasta ve kontrol grubundan elde edilen serumlarda Klamidyal lipopolisakkarit (cLPS) antijenine karşı gelişen IgG tipi antikorlar bir ticari ELISA kiti kullanılarak belirlendi. Bulgular: Yirmibir hastanın 11'inde (% 52.4), 17 kontrol olgusunun 6'smda (% 35.3) cLPS seropozitifliği tespit edildi. Hastalarda elde edilen seropozitiflik kontrol grubundakinden daha yüksek bulunmasına rağmen iki grup arasında istatistiksel olarak anlamlı bir fark görülmedi (P=0.468). Sonuç: Sonuçlarımız C. pneumoniae infeksiyonu ile KAH arasında ilişki olduğu hipotezini desteklememektedir.
Coronary artery disease and Chlamydia pneumoniae
Objective: Recent studies suggested that atherosclerosis may be associated with some bacterial ör viral agents. in this study we aimed to investigate the relationship betvveen Chlamydia pneumoniae (C. pneumoniae) infection and the atherosclerotic coronary artery disease (CAD). Methods: Twenty-one patients with CAD and 17 healthy people were recruited for this case-control study. Venous blood was taken from the patients before the coronary artery bypass greft operation. Immunoglobulip G type antibodies against Chlamydia lipopolysaccharide (cLPS) antigen were analyzed using a commercial ELISA in serums obtained from patients and control subjects. Results: Eleven of the 21 patients (52.4%) and 6 of the 17 control subjects (35.3%) were seropositive for cLPS. Although the rate of the seropositivity of the patients were higher than that of controls, there was no statistically signifıcant difference betvveen the groups (P=0.468). Conclusions: Our results indicate no association between C. pneumoniae infection and CAD.
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